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3. Epithelial Phenotypic Changes Detect Cyclosporine In Vivo Nephrotoxicity at a Reversible Stage

Author

Galichon, Pierre, Vittoz, Nathalie, Xu-Dubois, Yi-Chun, Cornaire, Emilie, Vandermeersch, Sophie, Mesnard, Laurent, Hertig, Alexandre, and Rondeau, Eric

Abstract

A widely used immunosuppressant, cyclosporine A (CsA), conveys long-term nephrotoxicity in some patients. However, no specific marker is presently available. In both native and transplanted human kidneys, epithelial phenotypic changes (EPCs) suggestive of epithelial to mesenchymal transition (EMT) are expressed in various diseases and are prognostic with respect to progression of interstitial fibrosis. We hypothesized that CsA is able to trigger these EPCs in tubular cells in vivo.

Published
2011
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