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4 results on '"C Lama"'

1. THE IMPACT OF DONOR AGE ON LIVER TRANSPLANTATION: INFLUENCE OF DONOR AGE ON EARLY LIVER FUNCTION AND ON SUBSEQUENT PATIENT AND GRAFT SURVIVAL

Author

Luis Ibañez, Emilio Ramos, Antonio Rafecas, Xavier Xiol, C Lama, Juan Figueras, Eduardo Jaurrieta, Juan Fabregat, Jose Maria Ramon, Juli Busquets, Laura Lladó, and Jaume Torras

Subjects
Adult, Male, Aging, medicine.medical_specialty, Time Factors, Adolescent, medicine.medical_treatment, Population, Liver transplantation, Cause of Death, medicine, Humans, Risk factor, Child, education, Survival analysis, Aged, Aged, 80 and over, Transplantation, education.field_of_study, Donor selection, business.industry, Graft Survival, Middle Aged, Survival Analysis, Tissue Donors, Liver Transplantation, Surgery, Liver, Relative risk, Female, Liver function, business, Follow-Up Studies
Abstract

Background. The urgent need to increase the organ donor pool has led to the expansion of criteria for donor selection. The aim of this study was to analyze the influence of donor age on early graft function, subsequent graft loss, and mortality after liver transplantation (LT). Methods. Data on LT were evaluated retrospectively in a population-based cohort of 400 LTs in 348 patients. Of these, 21 (5%) were from donors >70 years old. Pretransplantation donor and recipient characteristics and the evolution of recipients were analyzed. The influence of donor age as a risk factor was assessed using univariate and multivariate analyses. Results. Actuarial graft survival was 89% at 1 month after LT, 81% after 6 months, and 59% after 60 months. Multivariate analysis demonstrated that only donor age (>70 years old) was associated with a higher risk of long-term graft loss (relative risk [RR] = 1.4, 95% confidence interval [CI] = 1-1.9; P=0.03) and mortality (RR=1.7, 95% CI=1.2-2.3; P=0.01). Graft survival of septuagenarian livers was 80% at 1 month after LT, 56% after 6 months, and 25% after 54 months. Actuarial survival analysis (Kaplan-Meier curves) also demonstrated worse evolution in recipients of livers from old donors (log-rank test, P

Published
2001
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2. Results of using the recipient's splenic artery for arterial reconstruction in liver transplantation in 23 patients

Author

C Lama, Emilio Ramos, Antonio Rafecas, Jaume Torras, Eduardo Jaurrieta, Laura Lladó, Humberto Aranda, Juan Figueras, Juan Fabregat, and David Parés

Subjects
Reoperation, Transplantation, medicine.medical_specialty, Aorta, Hepatic veno-occlusive disease, business.industry, medicine.medical_treatment, Anastomosis, Surgical, Hepatic Veno-Occlusive Disease, Aorta, Thoracic, Anastomosis, Splenic artery, Liver transplantation, medicine.disease, Surgery, Liver Transplantation, Surgical anastomosis, Hepatic Artery, medicine.artery, Splenic infarction, medicine, Humans, business, Splenic Artery
Abstract

Background Arterial reconstruction is essential in liver transplantation. In some patients there may be an inadequate flow as a result of stenosis, intimal dissection, or anomalies of the hepatic artery. Methods This study analyzes our experience with 23 patients in whom arterial anastomosis was performed using the splenic artery due to the inadequacy of the hepatic artery. During the same period an aortoiliac conduit was used in 12 liver transplantations due to the same problem. Results No splenic infarction, pancreatitis, or other related complications were found. Artery thrombosis developed in only two patients in the aortoiliac conduit group. One- and three-year patient actuarial survival were 78% vs. 80% and 72% vs. 80%, respectively, for the splenic artery group and the aortoiliac conduit group. Conclusions Anastomosis with the splenic artery is an alternative in liver transplantation and is particularly suitable when splenomegaly is present.

Published
1997

3. The impact of donor age on liver transplantation: influence of donor age on early liver function and on subsequent patient and graft survival.

Author

Busquets J, Xiol X, Figueras J, Jaurrieta E, Torras J, Ramos E, Rafecas A, Fabregat J, Lama C, Ibañez L, Llado L, and Ramon JM

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Cause of Death, Child, Female, Follow-Up Studies, Graft Survival, Humans, Male, Middle Aged, Survival Analysis, Time Factors, Aging physiology, Liver physiopathology, Liver Transplantation, Tissue Donors
Abstract

Background: The urgent need to increase the organ donor pool has led to the expansion of criteria for donor selection. The aim of this study was to analyze the influence of donor age on early graft function, subsequent graft loss, and mortality after liver transplantation (LT)., Methods: Data on LT were evaluated retrospectively in a population-based cohort of 400 LTs in 348 patients. Of these, 21 (5%) were from donors >70 years old. Pretransplantation donor and recipient characteristics and the evolution of recipients were analyzed. The influence of donor age as a risk factor was assessed using univariate and multivariate analyses., Results: Actuarial graft survival was 89% at 1 month after LT, 81% after 6 months, and 59% after 60 months. Multivariate analysis demonstrated that only donor age (>70 years old) was associated with a higher risk of long-term graft loss (relative risk [RR]=1.4, 95% confidence interval [CI]=1-1.9; P=0.03) and mortality (RR=1.7, 95% CI=1.2-2.3; P=0.01). Graft survival of septuagenarian livers was 80% at 1 month after LT, 56% after 6 months, and 25% after 54 months. Actuarial survival analysis (Kaplan-Meier curves) also demonstrated worse evolution in recipients of livers from old donors (log-rank test, P<0.001)., Conclusions: Advanced donor age is associated with lower graft and recipient survival.

Published
2001
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4. Results of using the recipient's splenic artery for arterial reconstruction in liver transplantation in 23 patients.

Author

Figueras J, Parés D, Aranda H, Rafecas A, Fabregat J, Torras J, Ramos E, Lama C, Lladó L, and Jaurrieta E

Subjects
Anastomosis, Surgical methods, Aorta, Thoracic surgery, Hepatic Artery surgery, Hepatic Veno-Occlusive Disease etiology, Humans, Reoperation, Liver Transplantation, Splenic Artery surgery, Splenic Artery transplantation
Abstract

Background: Arterial reconstruction is essential in liver transplantation. In some patients there may be an inadequate flow as a result of stenosis, intimal dissection, or anomalies of the hepatic artery., Methods: This study analyzes our experience with 23 patients in whom arterial anastomosis was performed using the splenic artery due to the inadequacy of the hepatic artery. During the same period an aortoiliac conduit was used in 12 liver transplantations due to the same problem., Results: No splenic infarction, pancreatitis, or other related complications were found. Artery thrombosis developed in only two patients in the aortoiliac conduit group. One- and three-year patient actuarial survival were 78% vs. 80% and 72% vs. 80%, respectively, for the splenic artery group and the aortoiliac conduit group., Conclusions: Anastomosis with the splenic artery is an alternative in liver transplantation and is particularly suitable when splenomegaly is present.

Published
1997
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