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We aimed to identify, assess, compare and map research priorities of patients and professionals in the Swiss Transplant Cohort Study. The project followed 3 steps. 1) Focus group interviews identified patients' (n = 22) research priorities. 2) A nationwide survey assessed and compared the priorities in 292 patients and 175 professionals. 3) Priorities were mapped to the 4 levels of Bronfenbrenner's ecological framework. The 13 research priorities (financial pressure, medication taking, continuity of care, emotional wellbeing, return to work, trustful relationships, person-centredness, organization of care, exercise and physical fitness, graft functioning, pregnancy, peer contact and public knowledge of transplantation), addressed all framework levels: patient (n = 7), micro (n = 3), meso (n = 2), and macro (n = 1). Comparing each group's top 10 priorities revealed that continuity of care received highest importance rating from both (92.2% patients, 92.5% professionals), with 3 more agreements between the groups. Otherwise, perspectives were more diverse than congruent: Patients emphasized patient level priorities (emotional well-being, graft functioning, return to work), professionals those on the meso level (continuity of care, organization of care). Patients' research priorities highlighted a need to expand research to the micro, meso and macro level. Discrepancies should be recognized to avoid understudying topics that are more important to professionals than to patients. [ABSTRACT FROM AUTHOR]

Summary: Weight gain after liver transplantation (LTx) facilitates development of new‐onset obesity; however, its risk factors and outcomes are poorly understood. We identified the impact of new‐onset obesity on cardiovascular events (CVEs) and patient survival, and risk factors for new‐onset obesity. Multiple Cox regression models examined risk factors for CVEs, patient survival, and new‐onset obesity in 253 adults (mean age 52.2 ± 11.6 years, male gender 63.6%, mean follow up 5.7 ± 2.1 years). Cumulative incidence of post‐LTx CVE was 28.1%; that of new‐onset obesity was 21.3%. Regardless of CVE at LTx, post‐LTx CVEs were predicted by new‐onset obesity [Hazard Ratio (HR), 2.95; P = 0.002] and higher age at LTx (HR, 1.05; P < 0.001). In patients without known pre‐LTx CVEs (n = 214), risk factors for post‐LTx CVEs were new‐onset obesity (HR, 2.59; P = 0.014) and higher age (HR, 1.04; P = 0.001). Survival was not associated with new‐onset obesity (P = 0.696). Alcoholic liver disease predicted new‐onset obesity (HR, 3.37; P = 0.025), female gender was protective (HR, 0.39; P = 0.034). In 114 patients with available genetic data, alcoholic liver disease (HR, 12.82; P = 0.014) and hepatocellular carcinoma (HR, 10.02; P = 0.048) predicted new‐onset obesity, and genetics remained borderline significant (HR, 1.07; P = 0.071). Early introduction of post‐LTx weight management programs may suggest a potential pathway to reduce CVE risk. [ABSTRACT FROM AUTHOR]