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Your search keyword '"Nordin Adolfsson A"' showing total 2 results
Start Over Author "Nordin Adolfsson A" Journal translational psychiatry
2 results on '"Nordin Adolfsson A"'

2. The genomics of major psychiatric disorders in a large pedigree from Northern Sweden

Author

Jurgen Del-Favero, Jin P. Szatkiewicz, Annelie Nordin Adolfsson, James J. Crowley, Rolf Adolfsson, Maaike Alaerts, Patrick F. Sullivan, Steven A. McCarroll, Giulio Genovese, and Karolina A. Aberg

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Bipolar Disorder, Schizoaffective disorder, Genomics, Biology, Polymorphism, Single Nucleotide, Article, Psykiatri, lcsh:RC321-571, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Exome Sequencing, medicine, Humans, SNP, Bipolar disorder, Genetic risk, Psychiatry, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Biological Psychiatry, Aged, Oligonucleotide Array Sequence Analysis, Sweden, Whole Genome Sequencing, Case-control study, Middle Aged, medicine.disease, Pedigree, Psychiatry and Mental health, 030104 developmental biology, Psychotic Disorders, Schizophrenia, Case-Control Studies, Karyotyping, Female, Human medicine, 030217 neurology & neurosurgery
Abstract

We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.

Published
2019

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