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Your search keyword '"Fröhner, Juliane H."' showing total 5 results
Start Over Author "Fröhner, Juliane H." Journal translational psychiatry
5 results on '"Fröhner, Juliane H."'

1. Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning

Author

Owens, Max M., Albaugh, Matthew D., Allgaier, Nicholas, Yuan, Dekang, Robert, Gabriel, Cupertino, Renata B., Spechler, Philip A., Juliano, Anthony, Hahn, Sage, Banaschewski, Tobias, Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Lemaitre, Herve, Paus, Tomáš, Poustka, Luise, Millenet, Sabina, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Mackey, Scott, Schumann, Gunter, and Garavan, Hugh

Published
2022
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2. Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis

Author

Velthorst, Eva, Froudist-Walsh, Sean, Stahl, Eli, Ruderfer, Douglas, Ivanov, Ilyan, Buxbaum, Joseph, iPSYCH-Broad ASD Group, the IMAGEN consortium, Banaschewski, Tobias, Bokde, Arun L. W., Dipl-Psych, Uli Bromberg, Büchel, Christian, Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, and Reichenberg, Abraham

Published
2018
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3. Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?

Author

Kaminski, Jakob A., Schlagenhauf, Florian, Rapp, Michael, Awasthi, Swapnil, Ruggeri, Barbara, Deserno, Lorenz, Banaschewski, Tobias, Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Ittermann, Bernd, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Smolka, Michael N., Fröhner, Juliane H., Walter, Henrik, Whelan, Robert, Ripke, Stephan, Schumann, Gunter, Heinz, Andreas, and the IMAGEN consortium

Published
2018
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4. Differential predictors for alcohol use in adolescents as a function of familial risk.

Author

Tschorn, Mira, Lorenz, Robert C., O'Reilly, Paul F., Reichenberg, Abraham, Banaschewski, Tobias, Bokde, Arun L. W., Quinlan, Erin B., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Ittermann, Bernd, Martinot, Jean-Luc, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Millenet, Sabina, and Fröhner, Juliane H.

Published
2021
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5. Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis

Author

Velthorst, Eva, Froudist-Walsh, Sean, Stahl, Eli, Ruderfer, Douglas, Ivanov, Ilyan, Buxbaum, Joseph, Banaschewski, Tobias, Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Burke Quinlan, Erin, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Paillère Martinot, Marie Laure, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Reichenberg, Abraham, Børglum, Anders D., Grove, Jakob, Mattheisen, Manuel, Werge, Thomas, Mortensen, Preben Bo, Pedersen, Marianne Giørtz, Pedersen, Carsten Bøcker, Mors, Ole, Nordentoft, Merete, Hougaard, David M., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Hansen, Christine Søholm, Daly, Mark J., Neale, Benjamin M., Robinson, Elise B., Cerrato, Felecia, Dumont, Ashley, and Goldstein, Jacqueline

Subjects
Male, 0301 basic medicine, Multifactorial Inheritance, Psychosis, Adolescent, Autism Spectrum Disorder, Population, Structural equation modeling, lcsh:RC321-571, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Risk Factors, medicine, Humans, Genetic Predisposition to Disease, Social Behavior, education, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Biological Psychiatry, education.field_of_study, Brain/physiopathology, business.industry, Brain, medicine.disease, body regions, Psychiatry and Mental health, 030104 developmental biology, Psychotic Disorders, Autism spectrum disorder, Schizophrenia, Cohort, Psychotic Disorders/complications, Autism, Schizophrenia/complications, Female, Schizophrenic Psychology, business, human activities, 030217 neurology & neurosurgery, Social cognitive theory, Autism Spectrum Disorder/complications, Clinical psychology
Abstract

While psychotic experiences (PEs) are assumed to represent psychosis liability, general population studies have not been able to establish significant associations between polygenic risk scores (PRS) and PEs. Previous work suggests that PEs may only represent significant risk when accompanied by social impairment. Leveraging data from the large longitudinal IMAGEN cohort, including 2096 14-year old adolescents that were followed-up to age 18, we tested whether the association between polygenic risk and PEs is mediated by (increasing) impairments in social functioning and social cognitive processes. Using structural equation modeling (SEM) for the subset of participants (n = 643) with complete baseline and follow-up data, we examined pathways to PEs. We found that high polygenic risk for schizophrenia (p = 0.014), reduced brain activity to emotional stimuli (p = 0.009) and social impairments in late adolescence (p p = 0.025). These findings point to multiple direct and indirect pathways to PEs, suggesting that different processes are in play, depending on genetic loading, and environment. Our results suggest that treatments targeting prevention of social impairment may be particularly promising for individuals at genetic risk for autism in order to minimize risk for psychosis.

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