1. Non-genetic in vivo experimental models of epilepsy and vagus nerve stimulation
- Author
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W. A. Khachatryan, S. M. Malyshev, M. M. Galagudza, and T. M. Alekseeva
- Subjects
0301 basic medicine ,business.industry ,Experimental model ,medicine.medical_treatment ,medicine.disease ,Drug Resistant Epilepsy ,03 medical and health sciences ,Epilepsy ,030104 developmental biology ,0302 clinical medicine ,medicine ,business ,Neuroscience ,030217 neurology & neurosurgery ,Vagus nerve stimulation - Abstract
Complexity of epilepsy and a seizure as clinical and pathophysiological entities is reflected in a large number of experimental models of epilepsy. They could be stratified into acute and chronic, chemical and electric. The present review describes some most typical non-genetic models of different kinds used on laboratory rats. Also, the results of application of these models for research of vagus nerve stimulation as a novel treatment of drug resistant epilepsy are summarized.
- Published
- 2018
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