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Clinical characteristics of blood donors may affect short- and long-term outcomes of transfusion recipients. The impact of donor sex and age on recipient outcomes have not yielded consistent results in observational studies. One recently published randomized controlled trial (iTADS) addressing the impact of donor sex on recipient outcomes noted no differences between a female versus male transfusion strategy; a second Canadian multicenter trial has just been funded. Other donor characteristics - including pregnancy history, smoking status, obesity, and chronic illnesses - remain incompletely explored. More robust clinical studies with vein-to-vein capabilities are needed to understand the complex interplay between donors and recipients. [ABSTRACT FROM AUTHOR]