1. Clostridium perfringens epsilon toxin: a malevolent molecule for animals and man?
- Author
-
Gillian Barth, Michel R. Popoff, Bradley G. Stiles, Holger Barth, Wilson College, Universität Ulm - Ulm University [Ulm, Allemagne], Bactéries anaérobies et Toxines, Institut Pasteur [Paris], G.B. and B.G.S. thank Wilson College for generous use of facilities that include computers, copiers and library services, University of Ulm, and Institut Pasteur [Paris] (IP)
- Subjects
Clostridium perfringens ,Health, Toxicology and Mutagenesis ,receptor ,[ SDV.TOX ] Life Sciences [q-bio]/Toxicology ,lcsh:Medicine ,Review ,Toxicology ,medicine.disease_cause ,Mice ,MESH : Cattle ,therapeutics ,MESH: Animals ,Receptor ,MESH: Clostridium perfringens ,0303 health sciences ,protein toxin ,Goats ,Vaccination ,vaccines ,animal models ,3. Good health ,MESH: Cattle ,[SDV.TOX]Life Sciences [q-bio]/Toxicology ,MESH : Clostridium perfringens ,MESH: Clostridium Infections ,Bacterial Toxins ,MESH: Sheep ,Biology ,MESH : Sheep ,MESH: Goats ,Enteritis ,Microbiology ,03 medical and health sciences ,In vivo ,MESH : Mice ,medicine ,Animals ,Humans ,MESH: Mice ,030304 developmental biology ,cell culture ,MESH: Humans ,Sheep ,030306 microbiology ,Toxin ,MESH : Humans ,lcsh:R ,MESH: Vaccination ,Clostridium perfringens epsilon toxin ,medicine.disease ,Virology ,MESH : Disease Models, Animal ,In vitro ,MESH : Clostridium Infections ,Disease Models, Animal ,MESH : Goats ,MESH : Vaccination ,MESH: Bacterial Toxins ,Cell culture ,MESH : Bacterial Toxins ,Clostridium Infections ,Cattle ,MESH : Animals ,MESH: Disease Models, Animal - Abstract
International audience; Clostridium perfringens is a prolific, toxin-producing anaerobe causing multiple diseases in humans and animals. One of these toxins is epsilon, a 33 kDa protein produced by Clostridium perfringens (types B and D) that induces fatal enteric disease of goats, sheep and cattle. Epsilon toxin (Etx) belongs to the aerolysin-like toxin family. It contains three distinct domains, is proteolytically-activated and forms oligomeric pores on cell surfaces via a lipid raft-associated protein(s). Vaccination controls Etx-induced disease in the field. However, therapeutic measures are currently lacking. This review initially introduces C. perfringens toxins, subsequently focusing upon the Etx and its biochemistry, disease characteristics in various animals that include laboratory models (in vitro and in vivo), and finally control mechanisms (vaccines and therapeutics)
- Published
- 2013
- Full Text
- View/download PDF