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1. AFM1 Detection in Milk by Fab’ Functionalized Si3N4 Asymmetric Mach–Zehnder Interferometric Biosensors

Author

Tatevik Chalyan, Cristina Potrich, Erik Schreuder, Floris Falke, Laura Pasquardini, Cecilia Pederzolli, Rene Heideman, and Lorenzo Pavesi

Subjects
lab-on-chip, optical biosensors, Fab’, Aflatoxin M1, asymmetric Mach–Zehnder interferometer, limit of detection, affinity, Medicine
Abstract

Aflatoxins (AF) are naturally occurring mycotoxins, produced by many species of Aspergillus. Among aflatoxins, Aflatoxin M1 (AFM1) is one of the most frequent and dangerous for human health. The acceptable maximum level of AFM1 in milk according to EU regulation is 50 ppt, equivalent to 152 pM, and 25 ppt, equivalent to 76 pM, for adults and infants, respectively. Here, we study a photonic biosensor based on Si 3 N 4 asymmetric Mach–Zehnder Interferometers (aMZI) functionalized with Fab’ for AFM1 detection in milk samples (eluates). The minimum concentration of AFM1 detected by our aMZI sensors is 48 pM (16.8 pg/mL) in purified and concentrated milk samples. Moreover, the real-time detection of the ligand-analyte binding enables the study of the kinetics of the reaction. We measured the kinetic rate constants of the Fab’-AFM1 interaction.

Published
2019
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2. AFM1 Detection in Milk by Fab’ Functionalized Si3N4 Asymmetric Mach–Zehnder Interferometric Biosensors

Author

Laura Pasquardini, Erik Schreuder, Floris Falke, Lorenzo Pavesi, Rene Heideman, Tatevik Chalyan, Cristina Potrich, Cecilia Pederzolli, and Applied Physics and Photonics

Subjects
Aflatoxin, Health, Toxicology and Mutagenesis, Kinetics, lcsh:Medicine, 02 engineering and technology, Toxicology, Mach–Zehnder interferometer, 01 natural sciences, optical biosensors, Human health, chemistry.chemical_compound, heterocyclic compounds, AFLATOXIN M-1, PASTEURIZED MILK, RAPID DETECTION, M1, PERFORMANCE, IMMUNOASSAY, MYCOTOXINS, SENSOR, ELISA, Mycotoxin, Kinetic rate constant, Detection limit, limit of detection, Chromatography, Chemistry, lcsh:R, 010401 analytical chemistry, food and beverages, Fab’, 021001 nanoscience & nanotechnology, lab-on-chip, 0104 chemical sciences, asymmetric Mach–Zehnder interferometer, Aflatoxin M1, affinity, 0210 nano-technology, Biosensor
Abstract

Aflatoxins (AF) are naturally occurring mycotoxins, produced by many species of Aspergillus. Among aflatoxins, Aflatoxin M1 (AFM1) is one of the most frequent and dangerous for human health. The acceptable maximum level of AFM1 in milk according to EU regulation is 50 ppt, equivalent to 152 pM, and 25 ppt, equivalent to 76 pM, for adults and infants, respectively. Here, we study a photonic biosensor based on Si 3 N 4 asymmetric Mach&ndash, Zehnder Interferometers (aMZI) functionalized with Fab&rsquo, for AFM1 detection in milk samples (eluates). The minimum concentration of AFM1 detected by our aMZI sensors is 48 pM (16.8 pg/mL) in purified and concentrated milk samples. Moreover, the real-time detection of the ligand-analyte binding enables the study of the kinetics of the reaction. We measured the kinetic rate constants of the Fab&rsquo, AFM1 interaction.

Published
2019

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