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5. Phospholipase A2 inhibitors (βPLIs) are encoded in the venom glands of Lachesis muta (Crotalinae, Viperidae) snakes

Author

Lima, Rebeca Mascarenhas, Estevão-Costa, Maria Inácia, Junqueira-de-Azevedo, Inácio L.M., Lee Ho, Paulo, Vasconcelos Diniz, Marcelo Ribeiro, and Fortes-Dias, Consuelo Latorre

Subjects
*PHOSPHOLIPASE A2, *ENZYME inhibitors, *VENOM glands, *LACHESIS muta, *POISONOUS snakes, *NUCLEOTIDE sequence, *BLOOD circulation, *GLYCOPROTEINS
Abstract

Abstract: Phospholipase A2 inhibitors (PLIs) are glycoproteins secreted by snake liver into the circulating blood aiming the self-protection against toxic venom phospholipases A2. In the present study, we describe the first complete nucleotide sequence of a βPLI from venom glands of a New World snake, Lachesis muta. The deduced primary structure was compared to other known βPLIs and recent literature findings of other possible roles of PLIs in snakes are discussed. [ABSTRACT FROM AUTHOR]

Published
2011
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