235 results on '"Worek, Franz"'
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2. Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs
3. Determination of tissue distribution of VX and its metabolites EMPA and EA-2192 in various rat tissues by LC-ESI-MS/MS after phosphotriesterase treatment
4. Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents
5. The use of bispyridinium non-oxime analogues for the restoration of nerve agent impaired neuromuscular transmission in rat hemidiaphragms – Structure optimization
6. Inhibition kinetics of acetylcholinesterase and butyrylcholinesterase from various species by 2-(2-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP)
7. Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor
8. Toxicokinetic analysis of the highly toxic nerve agent VX in commercially available multi-organ-chips – Ways to overcome compound absorption
9. MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor
10. AChE reactivation in precision-cut lung slices following organophosphorus compound poisoning
11. The suitability of a polydimethylsiloxane-based (PDMS) microfluidic two compartment system for the toxicokinetic analysis of organophosphorus compounds
12. A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists
13. A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment
14. Inhibition of an organophosphate-detoxifying bacterial phosphotriesterase by albumin and plasma thiol components
15. Impact of soman and acetylcholine on the effects of propofol in cultured cortical networks
16. A catalytic bioscavenger with improved stability and reduced susceptibility to oxidation for treatment of acute poisoning with neurotoxic organophosphorus compounds
17. Screening of chiral shift reagents suitable to generically separate the enantiomers of V-agents by 31P-NMR spectroscopy
18. Novel cysteine- and albumin-adduct biomarkers to prove human poisoning with the pesticide oxydemeton-S-methyl
19. Cytostatic resistance profile of the sulfur mustard resistant keratinocyte cell line HaCaT/SM
20. Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning
21. Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity—An in vitro structure-activity analysis
22. Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism
23. Human small bowel as a useful tool to investigate smooth muscle effects of potential therapeutics in organophosphate poisoning
24. Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor
25. The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study
26. Effects of anti-inflammatory compounds on sulfur mustard injured cells: Recommendations and caveats suggested by in vitro cell culture models
27. Alteration of miRNA expression in a sulfur mustard resistant cell line
28. Development of a sensitive, generic and easy to use organophosphate skin disclosure kit
29. Blaptica dubia as sentinels for exposure to chemical warfare agents – a pilot study
30. Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes – Possible therapeutic implications
31. Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study
32. In vitro toxicokinetic studies of cyclosarin: Molecular mechanisms of elimination
33. Effectiveness of a substituted β-cyclodextrin to prevent cyclosarin toxicity in vivo
34. Detoxification of alkyl methylphosphonofluoridates by an oxime-substituted β-cyclodextrin – An in vitro structure–activity study
35. Elimination pathways of cyclosarin (GF) mediated by β-cyclodextrin in vitro: Pharmacokinetic and toxicokinetic aspects
36. New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (II). In vitro detoxification of cyclosarin (GF): General screening and toxicokinetic aspects of OP scavengers
37. New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: Evaluation of the detoxification using a half-quantitative enzymatic assay
38. Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase
39. Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase
40. Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning
41. Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat
42. HI 6 human serum albumin nanoparticles—Development and transport over an in vitro blood–brain barrier model
43. Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase
44. In vitro detoxification of cyclosarin (GF) by modified cyclodextrins
45. Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon
46. The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM)
47. Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro
48. Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman
49. Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection
50. On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit—Determination of reference values and their relevance for diagnosis of exposure to organophosphorus compounds
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