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Your search keyword '"Vicente-Vicente L"' showing total 15 results
Start Over Author "Vicente-Vicente L" Journal toxicology letters
15 results on '"Vicente-Vicente L"'

3. Pesticide exposure and risk of early kidney damage

Author

Casanova, A.G., primary, Martín-Reina, J., additional, Vicente-Vicente, L., additional, Tascón, J., additional, Prieto, M., additional, Pescador, M., additional, Bautista, J.D., additional, Moreno, I., additional, and Morales, A.I., additional

Published
2021
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4. Acute kidney injury predisposition induced by sub-nephrotoxic dosage of cisplatin disappears after 6 days

Author

Casanova, A.G., primary, Vicente-Vicente, L., additional, Hernández-Sánchez, M.T., additional, Rihuete, M.I., additional, Nieto, R., additional, Ramis, L.M., additional, del Barco, E., additional, Gómez-Bernal, A., additional, Cruz, J.J., additional, Sancho, S.M., additional, Prieto, M., additional, Pescador, M., additional, López-Hernández, F.J., additional, and Morales, A.I., additional

Published
2016
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8. Dosage interval of cisplatin-induced predisposition to acute kidney injury

Author

Casanova, A.G., primary, Vicente Vicente, L., additional, Hernández Sánchez, M.T., additional, Rihuete, M.I., additional, Nieto, R., additional, Ramis, L.M., additional, Gómez Bernal, A., additional, Sancho, S.M., additional, Prieto, M., additional, Pescador, M., additional, López Hernández, F.J., additional, and Morales, A.I., additional

Published
2016
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15. Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase.

Author

Vicente-Vicente L, Sánchez-Juanes F, García-Sánchez O, Blanco-Gozalo V, Pescador M, Sevilla MA, González-Buitrago JM, López-Hernández FJ, López-Novoa JM, and Morales AI

Subjects
Acute Kidney Injury enzymology, Acute Kidney Injury pathology, Acute Kidney Injury physiopathology, Acute Kidney Injury urine, Animals, Biomarkers urine, Disease Models, Animal, Gentamicins, Humans, Kidney enzymology, Kidney pathology, Kidney physiopathology, Kidney Tubular Necrosis, Acute chemically induced, Kidney Tubular Necrosis, Acute enzymology, Kidney Tubular Necrosis, Acute urine, Male, Rats, Wistar, Risk Assessment, Risk Factors, Time Factors, Up-Regulation, Acute Kidney Injury chemically induced, Antineoplastic Agents toxicity, Cisplatin toxicity, Hydrolases urine, Kidney drug effects
Abstract

Nephrotoxicity limits the therapeutic efficacy of the antineoplastic drug cisplatin. Due to dosage adjustment and appropriate monitoring, most therapeutic courses with cisplatin produce no or minimal kidney damage. However, we studied whether even sub-nephrotoxic dosage of cisplatin poses a potential risk for the kidneys by predisposing to acute kidney injury (AKI), specifically by lowering the toxicity threshold for a second nephrotoxin. With this purpose rats were treated with a single sub-nephrotoxic dosage of cisplatin (3mg/kg, i.p.) and after two days, with a sub-nephrotoxic regime of gentamicin (50mg/kg/day, during 6 days, i.p.). Control groups received only one of the drugs or the vehicle. Renal function and renal histology were monitored throughout the experiment. Cisplatin treatment did not cause any relevant functional or histological alterations in the kidneys. Rats treated with cisplatin and gentamicin, but not those under single treatments, developed an overt renal failure characterized by both renal dysfunction and massive tubular necrosis. In addition, the urinary excretion of fumarylacetoacetase was increased in cisplatin-treated animals at subtoxic doses, which might be exploited as a cisplatin-induced predisposition marker. In fact, the urinary level of fumarylacetoacetase prior to the second nephrotoxin correlated with the level of AKI triggered by gentamicin in predisposed animals., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)

Published
2015
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