1. Evaluation of LD50 of some polyaminocarboxylic acids used as chelating drugs in metal intoxication
- Author
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Jai Raj Behari, Mohd. Athar, Ramesh C. Srivastava, and P.P. Dwivedi
- Subjects
Stereochemistry ,Pentetic acid ,General Medicine ,Pentetic Acid ,Toxicology ,Median lethal dose ,Rats ,Metal ,Lethal Dose 50 ,chemistry.chemical_compound ,Structure-Activity Relationship ,Metal poisoning ,chemistry ,Metals ,visual_art ,Toxicity ,visual_art.visual_art_medium ,Animals ,Chelation ,Edetic Acid ,Female ,Chelation therapy ,Nuclear chemistry ,Chelating Agents - Abstract
The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA. A possible correlation between the toxicity and molecular structure of the compounds is discussed.
- Published
- 1986