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Your search keyword '"Duarte, José Alberto"' showing total 11 results
Start Over Author "Duarte, José Alberto" Publication Year Range Last 50 years Language english Journal toxicology letters
11 results on '"Duarte, José Alberto"'

11. Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases--a mechanistic approach.

Author

Baltazar MT, Dinis-Oliveira RJ, de Lourdes Bastos M, Tsatsakis AM, Duarte JA, and Carvalho F

Subjects
Animals, Apoptosis drug effects, Dieldrin toxicity, Environmental Exposure, Humans, Maneb toxicity, Organophosphates toxicity, Oxidative Stress, Paraquat toxicity, Proteasome Inhibitors toxicity, Pyrethrins toxicity, Neurodegenerative Diseases chemically induced, Parkinson Disease, Secondary chemically induced, Pesticides toxicity
Abstract

The etiology of most neurodegenerative disorders is multifactorial and consists of an interaction between environmental factors and genetic predisposition. The role of pesticide exposure in neurodegenerative disease has long been suspected, but the specific causative agents and the mechanisms underlying are not fully understood. For the main neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis there are evidences linking their etiology with long-term/low-dose exposure to pesticides such as paraquat, maneb, dieldrin, pyrethroids and organophosphates. Most of these pesticides share common features, namely the ability to induce oxidative stress, mitochondrial dysfunction, α-synuclein fibrillization and neuronal cell loss. This review aims to clarify the role of pesticides as environmental risk factors in genesis of idiopathic PD and other neurological syndromes. For this purpose, the most relevant epidemiological and experimental data is highlighted in order to discuss the molecular mechanisms involved in neurodegeneration., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)

Published
2014
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