1. An evaluation of the cardiac sensitizing potential of a fabric protector in aerosol form, containing 1,1,1-trichloroethane
- Author
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John L. Egle, Joseph F. Borzelleca, Glenn Stuart Simon, and James E. Long
- Subjects
Pharmacology ,Tachycardia ,Inhalation exposure ,Bradycardia ,Chromatography ,Inhalation ,Toxicology ,chemistry.chemical_compound ,medicine.anatomical_structure ,Epinephrine ,chemistry ,1,1,1-Trichloroethane ,Anesthesia ,Heart rate ,medicine ,medicine.symptom ,Sensitization ,medicine.drug - Abstract
Experiments were designed to assess the cardiac sensitizing potential of Scotchgard Brand Fabric Protector FC-4101 [which contains 1,1,1-trichloroethane (TCE)] under simulated misuse conditions. Beagle dogs were prepared for telemetric monitoring of their electrocardiogram (ECG) and placed in a 290-liter chamber. They were observed for possible effects of inhalation exposure to FC-4101, alone or in combination with intravenous epinephrine (8 and 16 μg/kg) and/or stress induced by a 2-sec blast from an air horn. The effects of inhaled pure TCE with Freon 12 propellant were also investigated. Changes in heart rate consisted of a bradycardia (presumably of reflex origin) due to epinephrine and stress, and a mild tachycardia following exposure to FC-4101 producing a concentration of 5000 ppm TCE in air. Following exposure to FC-4101 producing a concentration of 10,000 ppm TCE in air and following exposure to concentrations of 5000 ppm TCE in air and 10,000 ppm TCE in air with Freon 12 propellant, no tachycardia occurred. Inhalation of FC-4101 did not act synergistically with exogenous epinephrine (8 μg/kg) or endogenous epinephrine released in response to stress to induce cardiac arrhythmias. The arrhythmias induced by 16 μg/kg of epinephrine and stress were not intensified by the concurrent inhalation of FC-4101, 5000 ppm TCE. It is concluded that the simulated misuse conditions utilized in this study, FC-4101 and pure TCE with Freon 12 propellant did not cause cardiac sensitization.
- Published
- 1976