1. Influence of formaldehyde exposure on the molecules of the NO/cGMP-cAMP signaling pathway in different brain regions of Balb/c mice.
- Author
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Huang, Xiaoxiao, Cao, Fenghua, Zhao, Wei, Ma, Ping, Yang, Xu, and Ding, Shumao
- Subjects
CELLULAR signal transduction ,NITRIC oxide ,FORMALDEHYDE ,NITRIC-oxide synthases ,AIR pollutants ,MICE - Abstract
This toxicology study was conducted to assess the impact of formaldehyde, a common air pollutant found in Chinese gymnasiums, on the brain function of athletes. In this research, a total of 24 Balb/c male mice of SPF-grade were divided into four groups, each consisting of six mice. The mice were exposed to formaldehyde at different concentrations, including 0 mg/m
3 , 0.5 mg/m3 , 3.0 mg/m3 , and 3.0 mg/m3 in combination with an injection of L-NMMA (NG -monomethyl-L-arginine), which is a nitric oxide synthase antagonist. Following a one-week test period (8 h per day, over 7 days), measurements of biomarkers related to the nitric oxide (NO)/cGMP-cAMP signaling pathway were carried out on the experimental animals post-treatment. The study found that: (1) Exposure to formaldehyde can lead to brain cell apoptosis and neurotoxicity; (2) Additionally, formaldehyde exposure was found to alter the biomarkers of the NO/cGMP-cAMP signaling pathway, with some changes being statistically significant (p < 0.05 or p < 0.01); (3) The use of L-NMMA, an antagonist of the NO/cGMP-cAMP signaling pathway, was found to prevent these biomarker changes and had a protective effect on brain cells. The study suggests that the negative impact of formaldehyde on the brain function of mice is linked to the regulation of the NO/cGMP-cAMP signaling pathway. [ABSTRACT FROM AUTHOR]- Published
- 2024
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