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Introduction: Tobacco epidemic is a global public health concern, killing more than 8 million people annually. Individual therapy is the standard of care of behavioral intervention for smoking cessation in Malaysia and group-based therapy for smoking cessation is an alternative to behavioral intervention commonly used in the western population effectively. The study explored the feasibility and efficacy of group-based therapy for smoking cessation for smokers who want to quit smoking at a quit smoking clinic and community centers in an urban setting in Malaysia., Methods: A total of 40 participants who were active smokers and fulfilled the criteria were recruited for the study at the quit smoking clinic. Participants were given behavioral support based on the GBT-M module and individually for 7 weeks with both groups receiving behavioral intervention plus pharmacotherapy., Results: The median age of participants was 48 years for individual therapy and 45 years for group therapy. Group-based therapy was comparable to individual therapy in smoking abstinence outcome at 4 weeks post quit date (35% vs 30%)., Conclusions: Group-based therapy was equally effective compared to individual therapy, similar to the western population. Using a group format should allow more people to be treated by a therapist, and therefore could be more cost-effective. Group-based therapy is an option to be included as part of the smoking cessation program in Malaysia., Competing Interests: The authors have each completed and submitted an ICMJE form for disclosure of potential conflicts of interest. The authors declare that they have no competing interests, financial or otherwise, related to the current work. P.M. Rashidi Mohamed reports that since the initial planning of the work, this research was funded through a Universiti Malaya Grand Challenge grants GC004-15HTM and GC004C-15HTM and that in the past 36 months there was the patent planned, issued or pending 'Group therapy for smoking cessation module'. F. Mohd Hairi reports that since the initial planning of the work this study was supported by the Universiti Malaya Grand Challenge grant GC004C-15HTM. C. Bullen reports that in the past 36 months received consulting fees from Kenvue Asia Ltd, he received honorarium for keynote lecture at APSAD annual scientific meeting Sept. 2023, support for attending meetings and/or travel and an unpaid role in other board, society, committee or advocacy groups. A.S. Amer Nordin reports that since the initial planning of the work this study was supported by the Universiti Malaya Grand Challenge grant GC004C-15HTM and that in the past 36 months received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Johnson and Johnson Malaysia (he received an unconditional educational grant and have also spoken for J&J for smoking cessation product - Nicorette), and that he participated on a Data Safety Monitoring Board or Advisory Board as one of the advisors of the medical board of Bedfont Scientific Ltd., (© 2024 Rashidi Mohamed P.M. et al.)