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Your search keyword '"Vianello, Federica"' showing total 6 results
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6 results on '"Vianello, Federica"'

1. The Hobnail Variant of Papillary Thyroid Carcinoma: Clinical/Molecular Characteristics of a Large Monocentric Series and Comparison with Conventional Histotypes

Author

Watutantrige-Fernando, Sara, primary, Vianello, Federica, additional, Barollo, Susi, additional, Bertazza, Loris, additional, Galuppini, Francesca, additional, Cavedon, Elisabetta, additional, Censi, Simona, additional, Benna, Clara, additional, Ide, Eric Casal, additional, Parisi, Alessandro, additional, Nacamulli, Davide, additional, Iacobone, Maurizio, additional, Pennelli, Gianmaria, additional, and Mian, Caterina, additional

Published
2018
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2. High-Risk Patients with Differentiated Thyroid Cancer T4 Primary Tumors Achieve Remnant Ablation Equally Well Using rhTSH or Thyroid Hormone Withdrawal

Author

Bartenstein, Peter, primary, Calabuig, Elisa Caballero, additional, Maini, Carlo Ludovico, additional, Mazzarotto, Renzo, additional, Muros de Fuentes, M. Angustias, additional, Petrich, Thorsten, additional, Rodrigues, Fernando José Cravo, additional, Vallejo Casas, Juan Antonio, additional, Vianello, Federica, additional, Basso, Michela, additional, Balaguer, Marcelino Gómez, additional, Haug, Alexander, additional, Monari, Fabio, additional, Vaňó, Raquel Sánchez, additional, Sciuto, Rosa, additional, and Magner, James, additional

Published
2014
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3. MicroRNA Profiles in Familial and Sporadic Medullary Thyroid Carcinoma: Preliminary Relationships with RET Status and Outcome

Author

Mian, Caterina, primary, Pennelli, Gianmaria, additional, Fassan, Matteo, additional, Balistreri, Mariangela, additional, Barollo, Susi, additional, Cavedon, Elisabetta, additional, Galuppini, Francesca, additional, Pizzi, Marco, additional, Vianello, Federica, additional, Pelizzo, Maria Rosa, additional, Girelli, Maria Elisa, additional, Rugge, Massimo, additional, and Opocher, Giuseppe, additional

Published
2012
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6. BRAFK601E Mutation in a Patient with a Follicular Thyroid Carcinoma.

Author

Pennelli, Gianmaria, Vianello, Federica, Barollo, Susi, Pezzani, Raffaele, Merante Boschin, Isabella, Pelizzo, Maria Rosa, Mantero, Franco, Rugge, Massimo, and Mian, Caterina

Subjects
*CASE studies, *THYROID cancer treatment, *CYTOLOGY, *DIAGNOSTIC immunoblotting, *THYROIDECTOMY
Abstract

Background: BRAF mutations, the most common genetic alteration associated with papillary thyroid carcinoma (PTC), have never been associated with follicular thyroid carcinoma (FTC) except for one possible case, which, however, had some cellular features of the follicular variant of PTC. Here, we present a patient with a BRAF mutation within a FTC. Summary: A 78-year-old man presented with a nodular lesion 8 cm in size in the right thyroid lobe, coexisting with a goiter. Fine-needle aspiration samples were obtained for cytology, immunocytology, and molecular analysis. Immunoblot analysis on thyroid tissues was performed to evaluate the most important tumor activating pathways. Cytology was consistent with 'follicular neoplasia' (negative for galectin-3 immunostaining); molecular analysis on the cytology sample detected a K601E mutation in the exon 15 of the BRAF gene. After total thyroidectomy with lymph-node dissection, the diagnosis of FTC was established by histopathological examination. The BRAFK601E mutation was confirmed in DNA obtained from different areas of the FTC. In addition, an activating mutation (E545A) in the PKI3CA oncogene was found in the FTC. As expected, immunoblot analysis showed activation of the PI3K/Akt pathway. Conclusion: This article describes what may be the first case of a classical FTC carrying a BRAF mutation. Unlike the most common BRAF mutation seen in PTC carcinoma ( BRAFV600E), this patient's mutation was a BRAFK601E mutation that previously has been associated with some cases of the follicular variant of PTC. The BRAFK601E mutation should be included in the spectrum of genetic alterations in FTC. [ABSTRACT FROM AUTHOR]

Published
2011
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