Search

Your search keyword '"Finazzi G."' showing total 10 results
Start Over Author "Finazzi G." Journal thrombosis research
10 results on '"Finazzi G."'

2. PO-19 - Platelet (PLT) adhesion under flow condition in essential thrombocythemia (ET) and polycythemia vera (PV) is variably influenced according to patient mutational status

Author

Vignoli, A., primary, Tessarolo, S., additional, Marchetti, M., additional, Gamba, S., additional, Piras, F., additional, Finazzi, G., additional, van der Meijden, P.E.J., additional, Swieringa, F., additional, ten Cate, H., additional, Heemskerk, J.W.M., additional, Rambaldi, A., additional, and Falanga, A., additional

Published
2016
Full Text
View/download PDF

10. ADP-induced platelet aggregation and thrombin generation are increased in Essential Thrombocythemia and Polycythemia Vera.

Author

Panova-Noeva M, Marchetti M, Russo L, Tartari CJ, Leuzzi A, Finazzi G, Rambaldi A, ten Cate H, and Falanga A

Subjects
Adult, Aged, Aged, 80 and over, Aspirin therapeutic use, Blood Platelets drug effects, Blood Platelets metabolism, Female, Humans, Janus Kinase 2 genetics, Male, Middle Aged, Mutation, Platelet Aggregation Inhibitors therapeutic use, Polycythemia Vera drug therapy, Polycythemia Vera genetics, Polycythemia Vera metabolism, Thrombocythemia, Essential drug therapy, Thrombocythemia, Essential genetics, Thrombocythemia, Essential metabolism, Young Adult, Adenosine Diphosphate metabolism, Blood Platelets pathology, Platelet Aggregation drug effects, Polycythemia Vera pathology, Thrombin metabolism, Thrombocythemia, Essential pathology
Abstract

Introduction: Essential Thrombocythemia (ET) and Polycythemia Vera (PV) patients are characterized by an increased rate of thrombotic complications and by several abnormalities of platelets, more pronounced in JAK2V617F positive patients. The aim of this study was to characterize the platelet aggregation as well as the platelet procoagulant potential induced by several different agonists in ET and PV patients., Materials and Methods: Venous blood samples were obtained from 65 ET and 51 PV patients. Whole blood impedance aggregometry was utilized to characterize platelet aggregation induced by collagen, ADP, thrombin receptor activating peptide and arachidonic acid, while the Calibrated Automated Thrombogram (CAT) assay was used to determine the thrombin generation (TG) potential induced by ADP in platelet-rich plasma. CAT assay was also performed in the presence of annexin V to evaluate the contribution of platelet phospholipids to TG., Results and Conclusions: ADP-induced platelet aggregation and TG were significantly increased in ET and PV patients compared to controls. The highest values were observed in JAK2V617F positive patients and in patients on aspirin. In these subjects, annexin V was less effective in inhibiting both basal and ADP-induced TG. This study demonstrates for first time that platelets from ET and PV patients are more responsive to the ADP stimulus, in terms of both increased platelet aggregation, and enhanced TG, particularly in the JAK2V617F positive patients. Our data support the hypothesis that the use of ADP receptor inhibitors, in addition to aspirin, might be considered in the prevention of thrombosis in these conditions, by allowing a more complete inhibition of platelet functions., (Copyright © 2013 Elsevier Ltd. All rights reserved.)

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results