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20 results on '"Chilvers, Edwin R."'

6. Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT

Author

Farahi, Neda, primary, Gillett, Daniel, additional, Southwood, Mark, additional, Rassl, Doris, additional, Tregay, Nicola, additional, Hill, Uta, additional, Preston, Stephen Denis, additional, Loutsios, Chrystalla, additional, Lok, Laurence Si Chong, additional, Heard, Sarah, additional, Buscombe, John, additional, Rintoul, Robert Campbell, additional, Peters, A Michael, additional, Summers, Charlotte, additional, and Chilvers, Edwin R, additional

Published
2020
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11. Use of autologous 99mTechnetium-labelled neutrophils to quantify lung neutrophil clearance in COPD

Author

Tregay, Nicola, primary, Begg, Malcolm, additional, Cahn, Anthony, additional, Farahi, Neda, additional, Povey, Kathryn, additional, Madhavan, Sujith, additional, Simmonds, Rosalind, additional, Gillett, Daniel, additional, Solanki, Chandra, additional, Wong, Anna, additional, Maison, Joanna, additional, Lennon, Mark, additional, Bradley, Glyn, additional, Jarvis, Emily, additional, de Groot, Marius, additional, Wilson, Fred, additional, Babar, Judith, additional, Peters, A Michael, additional, Hessel, Edith M, additional, and Chilvers, Edwin R, additional

Published
2019
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13. Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis

Author

Pinder, Emma M, primary, Rostron, Anthony J, additional, Hellyer, Thomas P, additional, Ruchaud-Sparagano, Marie-Helene, additional, Scott, Jonathan, additional, Macfarlane, James G, additional, Wiscombe, Sarah, additional, Widdrington, John D, additional, Roy, Alistair I, additional, Linnett, Vanessa C, additional, Baudouin, Simon V, additional, Wright, Stephen E, additional, Chadwick, Thomas, additional, Fouweather, Tony, additional, Juss, Jatinder K, additional, Chilvers, Edwin R, additional, Bowett, Susan A, additional, Parker, Jennie, additional, McAuley, Daniel F, additional, Conway Morris, Andrew, additional, and Simpson, A John, additional

Published
2018
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14. Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury

Author

Proudfoot, Alastair, primary, Bayliffe, Andrew, additional, O’Kane, Cecilia M, additional, Wright, Tracey, additional, Serone, Adrian, additional, Bareille, Philippe Jean, additional, Brown, Vanessa, additional, Hamid, Umar I, additional, Chen, Younan, additional, Wilson, Robert, additional, Cordy, Joanna, additional, Morley, Peter, additional, de Wildt, Ruud, additional, Elborn, Stuart, additional, Hind, Matthew, additional, Chilvers, Edwin R, additional, Griffiths, Mark, additional, Summers, Charlotte, additional, and McAuley, Daniel Francis, additional

Published
2018
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15. Use of autologous 99mTechnetium-labelled neutrophils to quantify lung neutrophil clearance in COPD.

Author

Tregay, Nicola, Begg, Malcolm, Cahn, Anthony, Farahi, Neda, Povey, Kathryn, Madhavan, Sujith, Simmonds, Rosalind, Gillett, Daniel, Solanki, Chandra, Anna Wong, Maison, Joanna, Lennon, Mark, Bradley, Glyn, Jarvis, Emily, de Groot, Marius, Wilson, Fred, Babar, Judith, Peters, A. Michael, Hessel, Edith M., and Chilvers, Edwin R.

Subjects
NEUTROPHILS, LUNGS, SINGLE-photon emission computed tomography, LUNG volume, OBSTRUCTIVE lung diseases, LIPOPOLYSACCHARIDES, INTERLEUKINS, RESEARCH, RESEARCH evaluation, TECHNETIUM, RESEARCH methodology, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, IMMUNITY, RESEARCH funding
Published
2019
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16. Hypoxia upregulates neutrophil degranulation and potential for tissue injury

Author

Hoenderdos, Kim, primary, Lodge, Katharine M, additional, Hirst, Robert A, additional, Chen, Cheng, additional, Palazzo, Stefano G C, additional, Emerenciana, Annette, additional, Summers, Charlotte, additional, Angyal, Adri, additional, Porter, Linsey, additional, Juss, Jatinder K, additional, O'Callaghan, Christopher, additional, Chilvers, Edwin R, additional, and Condliffe, Alison M, additional

Published
2016
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19. Idiopathic pulmonary fibrosis or not: antibiotic prophylaxis for all patients on immunosuppressants.

Author

Neto, Manuel L. Ribeiro, Swigris, Jeffrey J., Culver, Daniel A., Shulgina, Ludmila, Cahn, Anthony P., Chilvers, Edwin R., Parfrey, Helen, Clark, Allan B., Wilson, Edward C. F., Twentyman, Orion P., Davison, Anthony G., Curtin, John J., Crawford, Michael B., and Wilson, Andrew M.

Subjects
IDIOPATHIC pulmonary fibrosis, CO-trimoxazole, CLINICAL trials, THERAPEUTICS
Abstract

A letter to the editor is presented in response to the article "Treating Idiopathic Pulmonary Fibrosis With the Addition of Co-Trimoxazole: A Randomized Controlled Trial." by L. Shulgina and colleagues in the 2013 issue.

Published
2013
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20. Use of autologous 99m Technetium-labelled neutrophils to quantify lung neutrophil clearance in COPD.

Author

Tregay N, Begg M, Cahn A, Farahi N, Povey K, Madhavan S, Simmonds R, Gillett D, Solanki C, Wong A, Maison J, Lennon M, Bradley G, Jarvis E, de Groot M, Wilson F, Babar J, Peters AM, Hessel EM, and Chilvers ER

Subjects
Aged, Biomarkers blood, Female, Humans, Interleukin-6 blood, Lipopolysaccharides, Male, Middle Aged, Neutrophil Infiltration drug effects, Neutrophil Infiltration physiology, Pulmonary Disease, Chronic Obstructive pathology, Reproducibility of Results, Single Photon Emission Computed Tomography Computed Tomography methods, Technetium, Lung diagnostic imaging, Neutrophils physiology, Pulmonary Disease, Chronic Obstructive diagnostic imaging
Abstract

Rationale: There is a need to develop imaging protocols which assess neutrophilic inflammation in the lung., Aim: To quantify whole lung neutrophil accumulation in (1) healthy volunteers (HV) following inhaled lipopolysaccharide (LPS) or saline and (2) patients with COPD using radiolabelled autologous neutrophils and single-photon emission computed tomography/CT (SPECT/CT)., Methods: 20 patients with COPD (Global initiative for chronic obstructive lung disease (GOLD) stages 2-3) and 18 HVs were studied. HVs received inhaled saline (n=6) or LPS (50 µg, n=12) prior to the injection of radiolabelled cells. Neutrophils were isolated using dextran sedimentation and Percoll plasma gradients and labelled with 99m Technetium (Tc)-hexamethylpropyleneamine oxime. SPECT was performed over the thorax/upper abdomen at 45 min, 2 hours, 4 hours and 6 hours. Circulating biomarkers were measured prechallenge and post challenge. Blood neutrophil clearance in the lung was determined using Patlak-Rutland graphical analysis., Results: There was increased accumulation of 99m Tc-neutrophils in the lungs of patients with COPD and LPS-challenged subjects compared with saline-challenged subjects (saline: 0.0006±0.0003 mL/min/mL lung blood distribution volume [mean ±1 SD]; COPD: 0.0022±0.0010 mL/min/mL [p<0.001]; LPS: 0.0025±0.0008 mL/min/mL [p<0.001]). The accumulation of labelled neutrophils in 10 patients with COPD who underwent repeat radiolabelling/imaging 7-10 days later was highly reproducible (0.0022±0.0010 mL/min/mL vs 0.0023±0.0009 mL/min/mL). Baseline interleukin (IL)-6 levels in patients with COPD were elevated compared with HVs (1.5±1.06 pg/mL [mean ±1 SD] vs 0.4±0.24 pg/mL). LPS challenge increased the circulating IL-6 levels (7.5±2.72 pg/mL) 9 hours post challenge., Conclusions: This study shows the ability to quantify 'whole lung' neutrophil accumulation in HVs following LPS inhalation and in subjects with COPD using autologous radiolabelled neutrophils and SPECT/CT imaging. Moreover, the reproducibility observed supports the feasibility of using this approach to determine the efficacy of therapeutic agents aimed at altering neutrophil migration to the lungs., Competing Interests: Competing interests: MB, AC, KP, SM, JM, ML, GB, EJ, MdG, FW and EMH are employees of GSK. NT, NF, RS, DG, CS, AW, JB, AMP and ERC have no competing interests to declare., (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.)

Published
2019
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