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1. [Comparison of blood pressure profile during exercise with benazepril 10 mg and benazepril 5 mg/hydrochlorothiazide 6.25 mg fixed combination]

Author

S, Boutelant, A, Francillon, J P, Siche, L, Cocco-Guyomarch, and J M, Mallion

Subjects
Adult, Male, Adolescent, Sodium Chloride Symporter Inhibitors, Physical Exertion, Blood Pressure, Drug Tolerance, Benzazepines, Middle Aged, Drug Combinations, Hydrochlorothiazide, Double-Blind Method, Humans, Female, Diuretics, Antihypertensive Agents, Aged
Abstract

This double-blind placebo-controlled study was designed to compare the efficacy of benazepril 10 mg (BZ 10) and the low-dose combination benazepril 5 mg/hydrochlorothiazide 6.25 mg (BZ + HCTZ) on exercise blood pressure in 71 patients with mild to moderate hypertension (diastolic blood pressure 95 to 114 mmHg at the end of a 2 week placebo run-in). A significant fall of systolic (SBF) and diastolic (DBP) blood pressure at rest was seen after a 4-week treatment period in the two active groups (-21.9/-10.3 mmHg with BZ 10, -19.5/-11.2 mmHg with BZ + HCTZ) and was greater in these two groups than in the placebo group (-7.5/-2.5 mmHg, p0.01). For each level of the exercise test on bicycle ergometer, SBP falls seen after 1 month were significant in the two active groups (from -15 to -23 mmHg depending on the level and treatment group). The evolution of the SBP/heart rate slope was significantly different among the two active groups in favour of the BZ 10 regimen. The exercise test proved to be a valuable tool to show any difference between two treatments with comparable efficacy on SBP/DBP at rest.

Published
1995

2. [Comparison of blood pressure profile during exercise with benazepril 10 mg and benazepril 5 mg/hydrochlorothiazide 6.25 mg fixed combination].

Author

Boutelant S, Francillon A, Siche JP, Cocco-Guyomarch L, and Mallion JM

Subjects
Adolescent, Adult, Aged, Antihypertensive Agents pharmacology, Benzazepines pharmacology, Diuretics, Double-Blind Method, Drug Combinations, Drug Tolerance, Female, Humans, Hydrochlorothiazide pharmacology, Male, Middle Aged, Physical Exertion, Sodium Chloride Symporter Inhibitors administration & dosage, Sodium Chloride Symporter Inhibitors pharmacology, Antihypertensive Agents administration & dosage, Benzazepines administration & dosage, Blood Pressure drug effects, Hydrochlorothiazide administration & dosage
Abstract

This double-blind placebo-controlled study was designed to compare the efficacy of benazepril 10 mg (BZ 10) and the low-dose combination benazepril 5 mg/hydrochlorothiazide 6.25 mg (BZ + HCTZ) on exercise blood pressure in 71 patients with mild to moderate hypertension (diastolic blood pressure 95 to 114 mmHg at the end of a 2 week placebo run-in). A significant fall of systolic (SBF) and diastolic (DBP) blood pressure at rest was seen after a 4-week treatment period in the two active groups (-21.9/-10.3 mmHg with BZ 10, -19.5/-11.2 mmHg with BZ + HCTZ) and was greater in these two groups than in the placebo group (-7.5/-2.5 mmHg, p < 0.01). For each level of the exercise test on bicycle ergometer, SBP falls seen after 1 month were significant in the two active groups (from -15 to -23 mmHg depending on the level and treatment group). The evolution of the SBP/heart rate slope was significantly different among the two active groups in favour of the BZ 10 regimen. The exercise test proved to be a valuable tool to show any difference between two treatments with comparable efficacy on SBP/DBP at rest.

Published
1995

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