9 results on '"Miremont-Salamé G"'
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2. Minors and young adult's hospitalizations after "chimique" consumption in Mayotte Island: Which substances are involved?
- Author
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Goncalves R, Peyré A, Castaing N, Beeken T, Olivier S, Combe P, Miremont-Salamé G, Titier K, Molimard M, and Daveluy A
- Subjects
- Male, Adolescent, Humans, Female, Young Adult, Adult, Comoros, Chromatography, Liquid methods, Tandem Mass Spectrometry methods, Hospitalization, Cannabinoids adverse effects, Cannabinoids metabolism, Illicit Drugs
- Abstract
Objectives: Over the last 10 years, the use of an unknown drug called "chimique" has emerged, among adolescents and young adults in precarious situations in Mayotte Island. To date, the exact composition of "chimique" is still poorly documented, but seizures made on the Island at the same time indicated that it would be mainly composed of synthetic cannabinoids receptor agonists (SCRAs). The objective of this study was to identify which substances, among those consumed under the name of "chimique", leading to hospital admissions., Methods: Between 1
st march and 30th June 2019, all patients, over 14 years old, hospitalized in the emergency department of Mayotte hospital after use of "chimique" for which the physician required toxicological analysis were included. Blood samples and clinical data were recorded for each patient. Toxicological analyses were performed using high resolution mass spectrometry (UPLC-MS/QTOF)., Results: Twelve patients were included: 11 males and 1 female. The mean age was 26 years (median age: 22). There were 2 minors. Clinical presentations varied, mainly psychiatric and neurologic disorders were observed. No death was reported. Toxicological analysis identified psychoactive substances such as THC and/or its metabolites (n=3) and MDMB-4en-PINCA (n=2). The other substances identified were mainly part of the patients' treatment., Conclusion: This is the first study conducted in the Indian Ocean confirming the presence of SCRAs in the "chimique". For a while, the consumption of SCRAs in France seemed to be of limited importance. However, their use has become important in the Indian Ocean since the spread of "chimique" in Mayotte. It continues to spread especially in Reunion Island since 2017 under the name of "chamane"., (Copyright © 2022 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.)- Published
- 2023
- Full Text
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3. [Ketamine use in outpatients: What can we learn from current practices?]
- Author
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Salvati A, Daveluy A, Claverie R, Miremont-Salamé G, Micallef J, and Frauger É
- Subjects
- Analgesics adverse effects, Humans, Outpatients, Palliative Care, Fibromyalgia, Ketamine adverse effects, Neuralgia
- Abstract
Introduction: Two off-label use of ketamine are framed by recommendations: in intractable pain in palliative situations or in postoperative pain. Ketamine is used in hospital but can also be used outside hospital with dispensations by hospital pharmacy to outpatients. Few data are available on ketamine use outside hospital. In this context, the French Addictovigilance Network has set up a study with hospital pharmacies., Materials and Methods: This survey assesses ketamine dispensations from 1 January to 30 April 2019, for patients who have an administration of ketamine outside hospital., Results: Sixty-five (65) hospital pharmacies have dispensed ketamine for 553 patients. Ketamine was indicated within non-palliative care in 86% of cases. Most of non-cancer pain were in fibromyalgia (44%) and neuropathic pain (29%). During the 4-month monitoring period, 1352 dispensations were analysed. The frequency of administration is daily in 91% of cases within palliative care whereas it is much more diverse within non-palliative care (33% daily, more than 15 different frequency in fibromyalgia). Within palliative care, ketamine is most administered intravenously or by Patient Controlled Analgesia or syringe pump (78% of cases) whereas in non-palliative care, ketamine is most used subcutaneously (44%), orally (32%) or both subcutaneously and orally (20%). A large number of ampoules could be dispensed (more than 30 ampoules for 10% of dispensations)., Conclusion: These data highlighted that recommendation in pain are not respected because most of ketamine is used within non-palliative care context and it should be noted a great heterogeneity of practice. This study underlines the urgency of targeted and clear information on certain off-label uses of ketamine for which no robust clinical studies are available and for which the risk of health complications like psychiatric (addiction), urologic and hepatologic complications is proven., (Copyright © 2022 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
4. [From psychoactive medicines to addictovigilance in French Public Health Code (1990-2017)].
- Author
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Baumevieille M, Perri-Plandé J, Miremont-Salamé G, Daveluy A, and Haramburu F
- Subjects
- France, Humans, Psychotropic Drugs adverse effects, Substance-Related Disorders epidemiology, Pharmacovigilance, Psychotropic Drugs administration & dosage, Public Health legislation & jurisprudence
- Abstract
Addictovigilance in the French Public Health Code, in the section related to poisonous substances, refers to a monitoring system developed since 1990: control of psychoactive substances and products, with medicinal use or not, was completed by a specific system focused on evaluation and information on pharmacodependance in 1999. The French medicines agency (Agence du médicament) created in 1993 was involved in this monitoring system; pharmacodependance evaluation was added by law to the missions of the agencies that followed: the Agence française de sécurité sanitaire des produits de santé missions (AFSSAPS, 1998) and the Agence nationale de sécurité du médicament et des produits de santé (ANSM, 2011). "Addictovigilance" first appears in French Law in 2017 whereas it was used by pharmacodependance centers and AFSSAPS since 2007. Legal definition of addictovigilance in the French Public Health Code testified to public authorities action against addictive behavior whatever products status, legal or not. The visibility of addictovigilance is growing on the Internet as well (ANSM website, web portal for reporting adverse health events)., (Copyright © 2018 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2019
- Full Text
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5. Causality assessment in pharmacovigilance: The French method and its successive updates.
- Author
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Miremont-Salamé G, Théophile H, Haramburu F, and Bégaud B
- Subjects
- Causality, Databases, Factual, Drug-Related Side Effects and Adverse Reactions diagnosis, France, Humans, Adverse Drug Reaction Reporting Systems, Drug-Related Side Effects and Adverse Reactions etiology, Pharmacovigilance
- Abstract
The methods for causality assessment of adverse drug reactions were developed in the 1970s and 1980s, alongside the development of pharmacovigilance. The French method is one of the earlier of these, following on from the pioneering works by Irey and Karch and Lasagna. Initially published in 1978, it was updated in 1985, and again in 2011. The main alterations to the original method are presented in tables annexed to this paper. The successive versions improved the presentation, provided more formalised definitions of the criteria for assessing causality, while at the same time ensuring the method remained easy to use. Causality assessment enables the causal link between a drug and the occurrence of an adverse reaction to be formalised and explained. It contributes to diagnosis, and to determining the action to be taken in case of an adverse drug reaction. It can contribute to the quality and the relevance of the data stored in pharmacovigilance databases., (Copyright © 2016 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2016
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6. Probable interaction between an oral vitamin K antagonist and turmeric (Curcuma longa).
- Author
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Daveluy A, Géniaux H, Thibaud L, Mallaret M, Miremont-Salamé G, and Haramburu F
- Subjects
- 4-Hydroxycoumarins administration & dosage, Administration, Oral, Anticoagulants administration & dosage, Female, Humans, Indenes administration & dosage, International Normalized Ratio, Middle Aged, Phenindione administration & dosage, Phenindione adverse effects, Vitamin K administration & dosage, Vitamin K adverse effects, 4-Hydroxycoumarins adverse effects, Anticoagulants adverse effects, Curcuma adverse effects, Hemorrhage chemically induced, Herb-Drug Interactions, Indenes adverse effects, Mitral Valve Insufficiency drug therapy, Phenindione analogs & derivatives, Vitamin K antagonists & inhibitors
- Abstract
We report a probable interaction between a vitamin K antagonist, fluindione, and the herbal medicine turmeric that resulted in the elevation of the international normalized ratio (INR). The case presented here underlines the importance of considering potential exposure to herbal medications when assessing adverse effects., (© 2014 Société Française de Pharmacologie et de Thérapeutique.)
- Published
- 2014
- Full Text
- View/download PDF
7. [Selective serotonin reuptake inhibitors and acne].
- Author
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Daveluy A, de Bazignan AD, Thiessard F, Miremont-Salamé G, Moore N, and Haramburu F
- Subjects
- Adolescent, Adult, Depression drug therapy, Female, Humans, Male, Middle Aged, Acne Vulgaris chemically induced, Selective Serotonin Reuptake Inhibitors adverse effects
- Published
- 2006
- Full Text
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8. [Terpenes in cosmetics: two cases of seizures].
- Author
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Laribière A, Miremont-Salamé G, Bertrand S, François C, and Haramburu F
- Subjects
- Camphor adverse effects, Child, Preschool, Cosmetics chemistry, Female, Humans, Infant, Intellectual Disability complications, Male, Terpenes chemistry, Cosmetics adverse effects, Seizures chemically induced, Terpenes adverse effects
- Published
- 2005
- Full Text
- View/download PDF
9. [Antidepressant adverse effects in the elderly: analysis of spontaneous reports in France].
- Author
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Daurel-Receveur M, Miremont-Salamé G, Fourrier A, Auriche P, Moore N, Bégaud B, and Haramburu F
- Subjects
- Adverse Drug Reaction Reporting Systems, Aged statistics & numerical data, Cardiovascular Diseases chemically induced, Cardiovascular Diseases epidemiology, France epidemiology, Humans, Metabolism drug effects, Aged physiology, Antidepressive Agents adverse effects
- Abstract
The prescription of antidepressants in the elderly has changed since the marketing of new antidepressants such as selective serotonin reuptake inhibitors (SSRIs). We analysed the adverse effects associated with antidepressants in subjects aged > or =75 years reported to the pharmacovigilance centres in France. Among the 2381 cases recorded between 1985 and 2001, the distribution of adverse effects may reflect sales figures: 1040 for SSRIs (44%), 586 for tricyclic and related antidepressants (25%), 46 for monoamine oxidase inhibitors (2%) and 654 for other antidepressants (27%). Adverse effect patterns differed according to antidepressant class. For SSRIs, hyponatraemia was predominant (30%), followed by psychiatric (13%) and nervous system (10%) effects. For tricyclic antidepressants, psychiatric effects (confusion, agitation) [21%] were the most frequent followed by cardiovascular effects (15%). However, the consequences of adverse effects such as hyponatraemia are far from negligible in the elderly.
- Published
- 2005
- Full Text
- View/download PDF
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