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Start Over Author "Durand, Alain" Journal therapeutic drug monitoring
7 results on '"Durand, Alain"'

1. A Rapid and Inexpensive Method for Anticipating Severe Toxicity to Fluorouracil and Fluorouracil-based Chemotherapy

Author

Ciccolini, Joseph, primary, Mercier, Cédric, additional, Evrard, Alexandre, additional, Dahan, Laetitia, additional, Boyer, Jean-Christophe, additional, Duffaud, Florence, additional, Richard, Karine, additional, Blanquicett, Carmelo, additional, Milano, Gérard, additional, Blesius, Aurore, additional, Durand, Alain, additional, Seitz, Jean-François, additional, Favre, Roger, additional, and Lacarelle, Bruno, additional

Published
2006
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2. Therapeutic Drug Monitoring for Dose Individualization of Cisplatin in Testicular Cancer Patients Based Upon Total Platinum Measurement in Plasma

Author

Salas, S??bastien, primary, Mercier, C??dric, additional, Ciccolini, Joseph, additional, Pourroy, Bertrand, additional, Fanciullino, Raphaelle, additional, Tranchand, Brigitte, additional, Monjanel-Mouterde, Suzanne, additional, Baciuchka-Palmaro, Marjorie, additional, Dupuis, Charlotte, additional, Yang, Chenguang, additional, Balti, Medhi, additional, Lacarelle, Bruno, additional, Duffaud, Florence, additional, Durand, Alain, additional, and Favre, Roger, additional

Published
2006
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3. Dose Individualization of Carboplatin After a 120-hour Infusion Schedule: Higher Dose Intensity but Fewer Toxicities

Author

Mercier, Cédric, primary, Ciccolini, Joseph, additional, Pourroy, Bertrand, additional, Fanciullino, Raphaelle, additional, Duffaud, Florence, additional, Digue, Laurence, additional, Tranchand, Brigitte, additional, Monjanel-Mouterde, Suzanne, additional, Guillet, Pierre, additional, Nicoara, Adriana, additional, Baciuchka, Marjorie, additional, Bagarry-Liegey, Danielle, additional, Lacarelle, Bruno, additional, Noble, Alex, additional, Durand, Alain, additional, and Favre, Roger, additional

Published
2006
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7. Dosage Adjustment of HighDose Methotrexate Using Bayesian Estimation

Author

Pignon, Thierry, Lacarelle, Bruno, Duffaud, Florence, Guillet, Pierre, Catalin, Jacques, Durand, Alain, and Favre, Roger

Abstract

Bayesian estimation (BE) of pharmacokinetic parameters enables the clinician to adjust the dosage of high-dose methotrexate (HDMTX) to correct the inter- and intraindividual variation of concentrations that are responsible for severe toxicity. In this study of 672 HDMTX infusions, we validated an approach that consisted of reaching as nearly as possible a theoretical concentration of 5.10-4Mor 10-3Mat the end of an 8-h infusion by adjusting, when necessary, the dosage at the 6th h. The BE of the clearance was compared with that obtained by maximum likelihood estimation (MLE), which was used as reference. BE performance was evaluated by calculating the bias and precision that indicated an overestimation of clearances obtained by BE compared with the higher clearance of the MLE in the group of patients receiving the higher dose (15 and 37.9). Linear regression analysis of clearance obtained by BE and MLE showed a correlation (p < 0.0001) in both groups of patients with a closer link in those with the lower dose. However, in current clinical practice the important point is to obtain MTX concentration that is as close as possible to the desired concentration. Adjustments were evaluated by comparing the obtained concentrations with the desired theoretical concentration. There was no bias and precision was satisfactory in both groups of patients (15 and 12, respectively, for 5.10-4Mand 10-3M). This method makes it possible to limit the inter- and intraindividual variations of concentrations. As a result, severe complications were essentially nonexistent and were never life threatening.

Published
1995

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