1. ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging
- Author
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Xuanzhong Xiao, Sha Zhu, Chenggen Qian, Xin Tang, Zhen Gu, Peijian Feng, Yu-Lei Chen, Quanyin Hu, Wujin Sun, Lei Zhang, Qun-Dong Shen, Yue Lu, and Jicheng Yu
- Subjects
theranostics ,Medicine (miscellaneous) ,Antineoplastic Agents ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Theranostic Nanomedicine ,stimuli-responsive ,chemistry.chemical_compound ,Adenosine Triphosphate ,In vivo ,ATP-responsive ,Humans ,Phenylboronic acid ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Drug Carriers ,Liver Neoplasms ,Optical Imaging ,Hep G2 Cells ,021001 nanoscience & nanotechnology ,Boronic Acids ,nanomedicine ,Controlled release ,Conjugated Polyelectrolytes ,0104 chemical sciences ,3. Good health ,chemistry ,Doxorubicin ,conjugated polymers ,drug delivery ,Drug delivery ,Nanoparticles ,Nanomedicine ,Nanocarriers ,0210 nano-technology ,Drug carrier ,Research Paper - Abstract
Stimuli-responsive and imaging-guided drug delivery systems hold vast promise for enhancement of therapeutic efficacy. Here we report an adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging. We demonstrate that the conjugated polymeric nanocarriers functionalized with phenylboronic acid tags on surface as binding sites for ATP could be converted to the water-soluble conjugated polyelectrolytes in an ATP-rich environment, which promotes the disassembly of the drug carrier and subsequent release of the cargo. In vivo studies validate that this formulation exhibits promising capability for inhibition of tumor growth. We also evaluate the metabolism process by monitoring the fluorescence signal of the conjugated polymer through the in vivo NIR imaging.
- Published
- 2016
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