1. Socioeconomic Deprivation as Measured by the Index of Multiple Deprivation and Its Association with Low Sex Hormone Binding Globulin in Women
- Author
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Rachelle Donn, Ian Laing, Andrew Hartland, Mark Livingston, David J. McLernon, Anthony A. Fryer, and Adrian Heald
- Subjects
Gerontology ,Index (economics) ,Ethnic group ,030209 endocrinology & metabolism ,Multiple deprivation ,030204 cardiovascular system & hematology ,Q1 ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,Index of multiple deprivation ,BMI ,0302 clinical medicine ,Sex hormone-binding globulin ,RZ ,Ethnicity ,Medicine ,Women ,Study analysis ,Association (psychology) ,Socioeconomic status ,biology ,business.industry ,Biochemistry, Genetics and Molecular Biology(all) ,Type 2 diabetes ,R1 ,Sex hormone binding globulin ,biology.protein ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Objective: Sex hormone binding globulin (SHBG) is a marker of insulin resistance. Given established links between BMI and socioeconomic disadvantage, we investigated how SHBG varies by index of multiple deprivation (IMD). Research Design and Methods: Using laboratory data from a Midlands UK population of mixed ethnicity, we examined the relation between blood concentrations of SHBG and IMD in 1160 women aged between 17 and 71 years. Women with a serum SHBG >250 nmol/L were excluded. Results: Mean age was 28.7 (95% confidence interval (CI) 28.2-29.1) years. 48.2% of women were of Caucasian origin, 15.5% of Southern Asian ethnicity and 2.6% were of African or other origin (33.7% were of unknown origin). SHBG increased with age (Spearman’s ρ=0.195; p
- Published
- 2016
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