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2 results on '"Richard F. Schmidt"'

1. Reconstruction of cranial base defects using the medpor titan implant: Cranioplasty applications in acoustic neuroma surgery

Author

Zain Boghani, James K. Liu, Robert W. Jyung, Richard F. Schmidt, and Osamah J. Choudhry

Subjects
Adult, Male, Reoperation, medicine.medical_specialty, medicine.medical_treatment, Dentistry, Acoustic neuroma, Skull defect, Prosthesis Design, symbols.namesake, Acoustic neuroma surgery, medicine, Humans, Aged, Skull Base, business.industry, Neuroma, Acoustic, Middle Aged, Plastic Surgery Procedures, Surgical Mesh, medicine.disease, Magnetic Resonance Imaging, Cranioplasty, Surgery, Treatment Outcome, Otorhinolaryngology, Skull base surgery, symbols, Female, Neurology (clinical), Implant, Polyethylenes, Titan (rocket family), business, Follow-Up Studies
Published
2013
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2. Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto's thyroiditis

Author

David Rosen, Ari Wirtschafter, Richard F. Schmidt, Marc Rosen, Joseph P. Atkins, Hinke A.B. Multhaupt, Alfredo Fusco, William M. Keane, Jay L. Rothstein, Nandita Kundu, and Massimo Santoro

Subjects
Adult, Male, endocrine system, Pathology, medicine.medical_specialty, endocrine system diseases, Gene Expression, Polymerase Chain Reaction, Thyroiditis, Papillary thyroid cancer, Thyroid carcinoma, Proto-Oncogene Proteins, medicine, Carcinoma, Biomarkers, Tumor, Drosophila Proteins, Humans, RNA, Messenger, Thyroid Neoplasms, Aged, DNA Primers, Autoimmune disease, Oncogene Proteins, business.industry, Thyroid, Proto-Oncogene Proteins c-ret, Thyroiditis, Autoimmune, Cancer, Receptor Protein-Tyrosine Kinases, RNA-Directed DNA Polymerase, Middle Aged, medicine.disease, Carcinoma, Papillary, medicine.anatomical_structure, Otorhinolaryngology, Female, business
Abstract

Hashimoto's thyroiditis is an inflammatory disease of the thyroid gland with autoimmune etiology. Patients afflicted with Hashimoto's have a higher risk of thyroid malignancies such as papillary thyroid carcinoma. In the present study, we investigated the frequency of papillary thyroid carcinoma specific genes in patients diagnosed with Hashimoto's disease. The newly identified oncogenes RET/PTC1 and RET/PTC3 provide useful and specific markers of the early stages of papillary carcinoma as they are highly specific for malignant cells. Using a sensitive and specific reverse transcriptase-polymerase chain reaction (RT-PCR) assay, we found messenger RNA (mRNA) expression for the RET/PTC1 and RET/PTC3 oncogenes in 95% of the Hashimoto's patients studied. All Hashimoto's patients presenting without histopathologic evidence of papillary thyroid cancer showed molecular genetic evidence of cancer. These data suggest that multiple, independent occult tumors exist in these patients at high frequency.

Published
1997

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