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2. Sequence similarities between human bornavirus isolates and laboratory strains question human origin

Author

Stephan Formella, Martin Schwemmle, Peter Staeheli, and Christian Jehle

Subjects
biology, Mental Disorders, Strain (biology), Genome, Viral, General Medicine, biology.organism_classification, Genome, Virology, Virus, Rats, Viral Proteins, Borna Disease, Sequence Homology, Nucleic Acid, Bornaviruses, Bornaviridae, Animals, Humans, Borna disease virus, Mononegavirales, Sequence (medicine)
Abstract

Summary Human bornavirus RW98, whose genome differs by 3–4% from previous isolates, is almost identical to a rat-adapted laboratory strain. Other human bornaviruses are also strongly related to virus strains frequently used for experiments in the various laboratories reporting human bornavirus, questioning a human origin of isolates known to date.

Published
1999
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