Search

Your search keyword '"Chiang, Feng-Yu"' showing total 25 results
Start Over Author "Chiang, Feng-Yu" Journal the kaohsiung journal of medical sciences
25 results on '"Chiang, Feng-Yu"'

1. Comparison of EMG signals recorded by surface electrodes on endotracheal tube and thyroid cartilage during monitored thyroidectomy

Author

Chiang, Feng-Yu, primary, Lu, I-Cheng, additional, Chang, Pi-Ying, additional, Dionigi, Gianlorenzo, additional, Randolph, Gregory W., additional, Sun, Hui, additional, Lee, Kang-Dae, additional, Tae, Kyung, additional, Ji, Yong Bae, additional, Kim, Sung Won, additional, Lee, Hyoung Shin, additional, and Wu, Che-Wei, additional

Published
2017
Full Text
View/download PDF

4. Exclusive real-time monitoring during recurrent laryngeal nerve dissection in conventional monitored thyroidectomy

Author

Liu, Xiao-Li, primary, Wu, Che-Wei, additional, Zhao, Yi-Shen, additional, Wang, Tie, additional, Chen, Peng, additional, Xin, Jing-Wei, additional, Li, Shi-Jie, additional, Zhang, Da-Qi, additional, Zhang, Guang, additional, Fu, Yan-Tao, additional, Zhao, Li-Na, additional, Zhou, Le, additional, Dionigi, Gianlorenzo, additional, Chiang, Feng-Yu, additional, and Sun, Hui, additional

Published
2016
Full Text
View/download PDF

24. Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps

Author

Wang, Ling‐Feng, Chien, Chen‐Yu, Tai, Chih‐Feng, Chiang, Feng‐Yu, and Chen, Jeff Yi‐Fu

Abstract

Eosinophils are important inflammatory cells involved in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). Vitamin D and its derivatives, in addition to their classic role as regulators of electrolytes homeostasis, have modulatory effects in immunological and inflammatory responses. Such properties suggest that vitamin D might also play a role in inflammatory airway diseases such as CRSwNP. In this study, we investigated the effect of vitamin D derivatives (calcitriol and tacalcitol) on the secretion of eotaxin and Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES), the two major eosinophil chemoattractants, in fibroblasts derived from the polyps of Taiwanese CRSwNP patients. Patients diagnosed with eosinophilic CRSwNP but without malignancies or asthma and undergoing elective endoscopic sinus surgery were recruited. Three primary fibroblast cultures were established using the polyp specimens obtained from these patients. The third to eighth passages of the fibroblasts were used for in vitrostudies. Nasal polyp‐derived fibroblasts were stimulated with IL‐1β (10 ng/mL) for 24 hours, followed by replacement with media alone or with calcitriol or tacalcitol (10μM) and incubation for another 24 hours. After the treatments, the levels of secreted eotaxin and RANTES were evaluated by ELISA assays. The results showed that IL‐1β could substantially stimulate the secretion of eotaxin (p< 0.01) and RANTES (p< 0.01) in nasal polyp‐derived fibroblasts. More importantly, this stimulatory effect was significantly suppressed by adding calcitriol (p≤ 0.002 for eotaxin and p≤ 0.008 for RANTES) or tacalcitol (p≤ 0.009 for eotaxin and p≤ 0.02 for RANTES). Therefore, the inhibitory effect of vitamin D derivatives on eotaxin and RANTES secretion might shed light not only on the disease mechanism, but also on the potential use of vitamin D in pharmacotherapy of Taiwanese patients with CRSwNP.

Published
2015
Full Text
View/download PDF

25. Expression of matrix metalloproteinase‐2 and matrix metalloproteinase‐9 in recurrent chronic rhinosinusitis with nasal polyposis

Author

Wang, Ling‐Feng, Chien, Chen‐Yu, Chiang, Feng‐Yu, Chai, Chee‐Yin, and Tai, Chih‐Feng

Abstract

Matrix metalloproteinase (MMP) is involved in the upper airway remodeling process. We hypothesized that MMP had an additive effect on the formation of recurrent nasal polyp. We also investigated the association between the functional promoter polymorphism of MMPs and the intensity of labeling index. Expressions of MMP‐2 and MMP‐9 were assessed via immunohistochemical staining and compared between different groups, including recurrent nasal polyps, nonrecurrent nasal polyps, and control nasal mucosa. Two promoter functional single‐nucleotide polymorphisms (rs3918242 for MMP‐9 and rs243865 for MMP‐2) were selected to correlate with staining intensity. Expression of MMP‐9 was significantly enhanced in gland for recurrent nasal polyp (p= 0.016) and nonrecurrent nasal polyp (p= 0.005) compared to the control. MMP‐2 positivity was significantly increased in surface epithelium for recurrent nasal polyp (p= 0.004) compared to the control (p= 0.061). However, there was no significant difference in MMP‐9 and MMP‐2 expressions between recurrent and nonrecurrent nasal polyps. Genetic polymorphism of MMP‐2 and MMP‐9 functional promoters was not associated with the intensity of labeling index. These results suggested that up‐regulation of MMP‐9 in gland and MMP‐2 in surface epithelium was characteristic of both recurrent and nonrecurrent nasal polyps. Pathogenesis of recurrent nasal polyps may involve a mechanism other than MMP.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results