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Start Over Author "Rosamaria Lisa" Journal the journals of gerontology series a: biological sciences and medical sciences
2 results on '"Rosamaria Lisa"'

1. A Genetic-Demographic Approach Reveals Male-Specific Association Between Survival and Tumor Necrosis Factor (A/G)-308 Polymorphism

Author

Rosamaria Lisa, Francesca Marchegiani, Maurizio Cardelli, Giovanna De Benedictis, Fabiola Oliveri, Francesco Lescai, Alberto Montesanto, Serena Dato, Luca Cavallone, Claudio Franceschi, Cardelli M., Cavallone L., Marchegiani F., Oliveri F., Dato S., Montesanto A., Lescai F., Lisa R., De Benedictis G., and Franceschi C.

Subjects
Adult, Male, Oncology, Aging, medicine.medical_specialty, media_common.quotation_subject, Longevity, Major histocompatibility complex, Internal medicine, Humans, Medicine, Allele, Longevity, genetics, Gene, Aged, media_common, Aged, 80 and over, Polymorphism, Genetic, biology, Tumor Necrosis Factor-alpha, business.industry, Haplotype, Tumor Necrosis Factor-alpha, genetics, Middle Aged, Immunology, Life expectancy, biology.protein, Microsatellite, Female, Tumor necrosis factor alpha, Geriatrics and Gerontology, business
Abstract

The (A/G)-308 polymorphism of the tumor necrosis factor alpha gene (TNF) is associated with age-related diseases, but its influence on longevity is controversial. We genotyped for this polymorphism 747 Italian volunteers (401 women and 346 men, age 19-110 years). By applying a genetic-demographic (GD) approach we found that, in men, the survival function of allele A carriers is lower than that of noncarriers at all the ages (p =.044). After defining (by exploiting again demographic information) three age classes, we found that the frequency of men carrying the A allele decreases with age (p =.019), thus confirming the GD analysis results. The same analyses gave negative results in women. Therefore, allele A has a detrimental effect on life expectancy, and this effect is specific to men. A haplotype analysis carried out in men by screening the TNFa, TNFc, and TNFe microsatellite polymorphisms (spanning about 20 kb) confirmed the association of the TNF region with life expectancy.

Published
2008
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2. A Polymorphism of the YTHDF2 Gene (1p35) Located in an Alu-Rich Genomic Domain Is Associated With Human Longevity

Author

Elena Mugianesi, Rosamaria Lisa, Raffaella Moresi, Luca Cavallone, Simona Giovagnetti, Claudio Franceschi, Maurizio Cardelli, Fabiola Olivieri, Francesca Marchegiani, Cardelli M., Marchegiani F., Cavallone L., Olivieri F., Giovagnetti S., Mugianesi E., Moresi R., Lisa R., and Franceschi C.

Subjects
Adult, Male, Aging, Adolescent, Genotype, Longevity, Alu element, Locus (genetics), Biology, Alu Elements, Humans, Lymphocytes, RNA, Messenger, Allele, Genotyping, Aged, Aged, 80 and over, Genetics, Messenger RNA, Polymorphism, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Middle Aged, Molecular biology, Introns, Microsatellite, Female, Human genome, Geriatrics and Gerontology
Abstract

The uneven distribution of Alu repetitive elements in the human genome is related to specific functional properties of genomic regions. We report the identification of a locus associated with human longevity in one of the chromosomal regions with the highest density of Alu elements, in 1p35. The locus, corresponding to a (TG)n microsatellite in the YTHDF2 gene, was identified by characterizing an ‘‘anonymous’’ marker detectable through interAlu fingerprinting, which previously evidenced an increased homozygosity in centenarians. After genotyping 412 participants of different ages, including 137 centenarians, we confirmed the increased homozygosity in centenarians at this locus, and observed a concomitantly increased frequency of the most frequent allele and the corresponding homozygous genotype. Remarkably, the same genotype was associated with increased YTHDF2 messenger RNA levels in immortalized lymphocytes. Finally, YTHDF2 messenger RNA resulted to be mainly expressed in testis and placenta. The data suggest a possible role of this locus in human longevity.

Published
2006
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