22 results on '"Paul Perrotte"'
Search Results
2. QUALITY OF LIFE AFTER SALVAGE CRYOTHERAPY
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PAUL PERROTTE, MARK S. LITWIN, EDWARD J. McGUIRE, SHELLIE M. SCOTT, ANDREW C. VON ESCHENBACH, and LOUIS L. PISTERS
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Urology - Published
- 1999
3. Survival benefit of radical prostatectomy in patients with localized prostate cancer: estimations of the number needed to treat according to tumor and patient characteristics
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Firas Abdollah, Rodolphe Thuret, Maxine Sun, Claudio Jeldres, Francesco Montorsi, Pierre I. Karakiewicz, Paul Perrotte, Marco Bianchi, Jan Schmitges, Shahrokh F. Shariat, Alberto Briganti, Abdollah, Fira, Sun, Maxine, Schmitges, Jan, Thuret, Rodolphe, Bianchi, Marco, Shariat Shahrokh, F., Briganti, Alberto, Jeldres, Claudio, Perrotte, Paul, Montorsi, Francesco, and Karakiewicz Pierre, I.
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Male ,medicine.medical_specialty ,Canada ,Time Factors ,Urology ,medicine.medical_treatment ,Risk Assessment ,Prostate cancer ,Prostate ,Risk Factors ,Medicine ,Humans ,Propensity Score ,Aged ,Retrospective Studies ,Aged, 80 and over ,Prostatectomy ,Health Services Needs and Demand ,business.industry ,Age Factors ,Prostatic Neoplasms ,Retrospective cohort study ,medicine.disease ,Prognosis ,United States ,Europe ,Survival Rate ,Prostate-specific antigen ,medicine.anatomical_structure ,Socioeconomic Factors ,Propensity score matching ,Number needed to treat ,Prostate surgery ,business ,SEER Program - Abstract
Purpose: The benefit of active treatment for prostate cancer is a subject of continuous debate. We assessed the relationship between treatment type (radical prostatectomy vs observation) and cancer specific mortality in a large, population based cohort. Materials and Methods: We examined the records of 44,694 patients treated with radical prostatectomy or observation between 1992 and 2005 in the SEER (Surveillance, Epidemiology and End Results)-Medicare linked database. Patients were matched by propensity score. Competing risks analysis was done to test the effect of treatment type on cancer specific mortality after accounting for other cause mortality. The number needed to treat was calculated. All analysis was stratified by prostate cancer risk group, baseline Charlson comorbidity index and patient age. Results: For patients treated with radical prostatectomy vs observation the 10-year cancer specific mortality rate was 5.2% vs 12.8% for high risk prostate cancer, 1.4% vs 3.8% for low-intermediate risk prostate cancer, 2.4% vs 5.8% for a Charlson comorbidity index of 0, 2.3% vs 6.4% for a comorbidity index of 1, 2.5% vs 5.4% for a comorbidity index of 2 or greater, 2.0% vs 4.6% at ages 65 to 69, 2.6% vs 5.6% at ages 70 to 74 and 2.7% vs 8.1% at ages 75 to 80 years (each p < 0.001). The corresponding number need to treat was 13, 42, 29, 24, 34, 38, 33 and 19, respectively. On multivariable analysis radical prostatectomy was an independent predictor of more favorable cancer specific mortality in all categories (each p < 0.001). Conclusions: Patients with high risk prostate cancer benefit the most from radical prostatectomy. The lowest benefit was observed in patients with low-intermediate risk prostate cancer. An intermediate benefit was observed when patients were classified by Charlson comorbidity index and age category.
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- 2011
4. Discharge patterns after radical cystectomy: contemporary trends in the United States
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Alberto Briganti, James O. Peabody, Maxine Sun, Marco Bianchi, Mani Menon, Jan Schmitges, Claudio Jeldres, Shahrokh F. Shariat, Craig G. Rogers, Khurshid R. Ghani, Francesco Montorsi, Pierre I. Karakiewicz, Quoc-Dien Trinh, Jesse D. Sammon, Paul Perrotte, Shyam Sukumar, Bianchi, M, Trinh, Qd, Sun, M, Sammon, J, Schmitges, J, Shariat, Sf, Sukumar, S, Ghani, Kr, Jeldres, C, Perrotte, P, Rogers, Cg, Briganti, Alberto, Peabody, Jo, Montorsi, Francesco, Menon, M, and Karakiewicz, Pi
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Adult ,Male ,Patient Transfer ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Context (language use) ,Logistic regression ,Cystectomy ,medicine ,Humans ,In patient ,Aged ,Patient discharge ,Aged, 80 and over ,business.industry ,Length of Stay ,Middle Aged ,Patient Discharge ,United States ,Surgery ,Late period ,Charlson comorbidity index ,Female ,business ,Medicaid ,Demography - Abstract
Purpose: Discharge patterns, including rates of prolonged length of stay and transfer to a facility, were evaluated in the context of radical cystectomy. Materials and Methods: Within the Nationwide Inpatient Sample we focused on radical cystectomy performed between 1998 and 2007. Multivariable logistic regression analyses predicting the likelihood of prolonged length of stay or transfer to a facility were performed. Results: Overall 11,876 eligible radical cystectomy cases were identified. The rates of prolonged length of stay decreased from 59% in the early period (1998 to 2001) to 50% in the late period (2005 to 2007, p < 0.001) while the rates of transfer to a facility remained stable (14%). On multivariable analyses adjusted for clustering, prolonged length of stay was more frequently recorded in patients from low annual caseload hospitals (OR 1.42, p < 0.001), as well as in Medicaid and Medicare patients (OR 1.66 and 1.17, respectively, all p < 0.01). Similarly rates of transfer to a facility were significantly higher for patients from low annual caseload hospitals (OR 1.81, p < 0.001) and for those with Medicaid or Medicare (OR 2.18 and 1.54, respectively, all p < 0.001), as well as for patients treated at nonacademic institutions (OR 1.31, p < 0.001). Conclusions: It is encouraging that the rates of prolonged length of stay have decreased while the rates of transfer to a facility remained stable. However, it is worrisome that individuals treated at low annual caseload centers as well as those with Medicare and Medicaid insurance experience less favorable discharge patterns.
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- 2011
5. Radical prostatectomy at academic versus nonacademic institutions: a population based analysis
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Shyam Sukumar, Maxine Sun, Zhe Tian, Marco Bianchi, James O. Peabody, Pierre I. Karakiewicz, Quoc-Dien Trinh, Jan Schmitges, Markus Graefen, Mani Menon, Jesse D. Sammon, Claudio Jeldres, Shahrokh F. Shariat, and Paul Perrotte
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Adult ,Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Blood Loss, Surgical ,Population based ,Logistic regression ,Academic institution ,Hospitals, University ,Postoperative Complications ,Health care ,Outcome Assessment, Health Care ,medicine ,Humans ,Blood Transfusion ,Intraoperative Complications ,Aged ,Aged, 80 and over ,Prostatectomy ,business.industry ,Confounding ,Length of Stay ,Middle Aged ,Surgery ,Logistic Models ,Homologous blood ,Family medicine ,Charlson comorbidity index ,business - Abstract
Radical prostatectomy outcomes may be better at academic institutions than at nonacademic centers. We examined the effect of academic status on 5 short-term radical prostatectomy outcomes.In the Health Care Utilization Project Nationwide Inpatient Sample we focused on radical prostatectomy performed within the 7 most contemporary years (2001 to 2007). We tested the rates of homologous blood transfusions and extended length of stay, as well as intraoperative and postoperative complications stratified according to institutional academic status. Multivariable logistic regression analyses further adjusted for confounding variables.Overall 89,965 radical prostatectomies were identified, yielding a weighted national estimate of 442,811. Of those procedures 58.2% were recorded at academic institutions. Patients at academic institutions had a lower Charlson comorbidity index and more frequently had private insurance (p0.001). Radical prostatectomy at academic institutions was associated with fewer blood transfusions (5.4% vs 7.4%), fewer postoperative complications (10.1% vs 12.9%) and lower rates of hospital stay above the median (18.0% vs 28.2%). On multivariable analyses institutional academic status exerted a protective effect on postoperative complication rates (OR 0.93, p = 0.02) and on rates of hospital stay in excess of the median (OR 0.91, p0.001). Similarly radical prostatectomy performed at hospitals with a high annual caseload were less frequently associated with intraoperative (OR 0.8, p = 0.01) and postoperative (OR 0.63, p0.001) complications, length of stay beyond the median (OR 0.19, p0.001) and homologous blood transfusions (OR 0.35, p0.001).Even after adjusting for annual hospital caseload, radical prostatectomy performed at academic institutions is associated with better outcomes than radical prostatectomy performed at nonacademic institutions. This relationship illustrates averages and does not imply that academic institutions invariably offer better care.
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- 2011
6. Hospital and surgical caseload are predictors of comprehensive surgical treatment for bladder cancer: a population based study
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Rodolphe Thuret, Pierre I. Karakiewicz, Paul Perrotte, Claudio Jeldres, Shahrokh F. Shariat, Maxine Sun, Jan Schmitges, Markus Graefen, Firas Abdollah, Orchidee Djahangirian, Francesco Montorsi, Abdollah, Fira, Schmitges, Jan, Sun, Maxine, Thuret, Rodolphe, Djahangirian, Orchidee, Jeldres, Claudio, Shariat Shahrokh, F., Graefen, Marku, Perrotte, Paul, Montorsi, Francesco, and Karakiewicz Pierre, I.
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Urology ,medicine.medical_treatment ,Cystectomy ,Gee ,medicine ,Humans ,Surgical treatment ,Lymph node ,Aged ,Retrospective Studies ,Aged, 80 and over ,Bladder cancer ,business.industry ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Hospitals ,United States ,Surgery ,Population based study ,Dissection ,medicine.anatomical_structure ,Urinary Bladder Neoplasms ,Lymph Node Excision ,business ,Forecasting - Abstract
Purpose: In patients with nonmetastatic muscle invasive bladder cancer, radical cystectomy and pelvic lymph node dissection represent a comprehensive surgical treatment. We tested the hypothesis that radical cystectomy performed at a high caseload hospital and/or by a high caseload surgeon is more likely to include pelvic lymph node dissection. Materials and Methods: We identified 12,274 patients with bladder cancer treated with radical cystectomy between 1998 and 2007 within the Nationwide Inpatient Sample. Univariable and multivariable analyses tested the relationship between hospital and surgical caseload at radical cystectomy, and the pelvic lymph node dissection rate. Generalized estimating equation models were used to adjust for clustering among hospitals and surgeons. Results: Overall 70% of patients received comprehensive surgical treatment defined as radical cystectomy and pelvic lymph node dissection. The pelvic lymph node dissection rate was 63% vs 67% vs 80% for low vs intermediate vs high annual hospital caseload tertiles, respectively (p
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- 2011
7. Tumor grade improves the prognostic ability of American Joint Committee on Cancer stage in patients with penile carcinoma
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Mathieu Latour, Daniel Liberman, Maxine Sun, Giovanni Lughezzani, Rodolphe Thuret, Monica Morgan, Paul Perrotte, Firas Abdollah, François Iborra, Pierre I. Karakiewicz, Lars Budäus, Shahrokh F. Shariat, Jean-Jacques Patard, Claudio Jeldres, J Guiter, Rupinder Johal, Service Urologie [Lapeyronie], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Cancer Prognostics and Health Outcomes Unit, Université de Montréal (UdeM), Department of urology, Università Vita-Salute San Raffaele, Martini-Clinic, Prostate Cancer Center Hamburg-Eppendorf, Department of Urology, Service d'urologie [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Service d'urologie [Rennes] = Urology [Rennes], Hôpital Pontchaillou-CHU Pontchaillou [Rennes], and De Villemeur, Hervé
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Oncology ,Male ,030232 urology & nephrology ,MESH: Lymph Nodes ,Kaplan-Meier Estimate ,MESH: Risk Assessment ,[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology ,MESH: Proportional Hazards Models ,0302 clinical medicine ,Penile Carcinoma ,Surveillance, Epidemiology, and End Results ,MESH: Incidence ,Stage (cooking) ,Societies, Medical ,MESH: Middle Aged ,Incidence ,Biopsy, Needle ,MESH: Guidelines as Topic ,MESH: Carcinoma, Squamous Cell ,MESH: Neoplasm Staging ,Middle Aged ,Prognosis ,Primary tumor ,Immunohistochemistry ,MESH: Predictive Value of Tests ,3. Good health ,MESH: Young Adult ,030220 oncology & carcinogenesis ,Predictive value of tests ,MESH: Survival Analysis ,Carcinoma, Squamous Cell ,MESH: SEER Program ,MESH: Neoplasm Recurrence, Local ,MESH: Rare Diseases ,Adult ,medicine.medical_specialty ,MESH: Biopsy, Needle ,Urology ,MESH: Societies, Medical ,MESH: Nomograms ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Guidelines as Topic ,Risk Assessment ,MESH: Multivariate Analysis ,MESH: Prognosis ,Disease-Free Survival ,03 medical and health sciences ,Young Adult ,MESH: Penile Neoplasms ,Age Distribution ,Rare Diseases ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Predictive Value of Tests ,Internal medicine ,MESH: Analysis of Variance ,medicine ,Carcinoma ,Penile cancer ,Humans ,MESH: Age Distribution ,Penile Neoplasms ,MESH: Kaplan-Meier Estimate ,Neoplasm Staging ,Proportional Hazards Models ,Analysis of Variance ,MESH: Humans ,business.industry ,Cancer ,MESH: Adult ,MESH: Immunohistochemistry ,medicine.disease ,[SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology ,Survival Analysis ,MESH: Male ,Surgery ,Nomograms ,MESH: Disease-Free Survival ,Multivariate Analysis ,Lymph Nodes ,Neoplasm Recurrence, Local ,business ,SEER Program - Abstract
International audience; PURPOSE: Penile cancer is rare. Thus, predicting cancer specific mortality may be difficult. We devised an accurate and yet easily applicable predictive rule that compares favorably with 2 previous models (73.8% and 74.7% accuracy, respectively). MATERIALS AND METHODS: We identified patients treated with primary tumor excision for all stages of penile squamous cell carcinoma between 1998 and 2006. Disease stage definitions using Surveillance, Epidemiology and End Results stage, American Joint Committee on Cancer stage and TNM classification, and tumor grade were used to predict cancer specific mortality. Predictive accuracy estimates were compared using the DeLong method for related AUCs. RESULTS: Surveillance, Epidemiology and End Results stage alone (1 predictor variable) was least accurate (74.5%). American Joint Committee on Cancer stage with tumor grade (2 predictor variables) was the most simple and most accurate (80.9%, p
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- 2010
8. Annual surgical caseload and open radical prostatectomy outcomes: improving temporal trends
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Shahrokh F. Shariat, Lars Budäus, Maxine Sun, Markus Graefen, Kevin C. Zorn, Rodolphe Thuret, Monica Morgan, Pierre I. Karakiewicz, Firas Abdollah, Francesco Montorsi, Paul Perrotte, Rupinder Johal, Hendrik Isbarn, Budeaus, Lar, Abdollah, Fira, Sun, Maxine, Morgan, Monica, Johal, Rupinder, Thuret, Rodolphe, Zorn Kevin, C., Isbarn, Hendrik, Shariat Shahrokh, F., Montorsi, Francesco, Perrotte, Paul, Graefen, Marku, and Karakiewicz Pierre, I.
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Adult ,Aged, 80 and over ,Male ,Prostatectomy ,medicine.medical_specialty ,Standard of care ,Time Factors ,business.industry ,Genitourinary system ,Urology ,General surgery ,medicine.medical_treatment ,Prostatic Neoplasms ,Middle Aged ,Logistic regression ,medicine.disease ,Surgery ,Prostate cancer ,Treatment Outcome ,medicine ,Humans ,Clinical Competence ,business ,Aged - Abstract
Purpose: Radical prostatectomy is the standard of care for localized prostate cancer. Numerous previous reports show the relationship between surgical experience and various outcomes. We examined the effect of surgical experience on complications and transfusion rates, and determined individual surgeon annual caseload trends in a contemporary radical prostatectomy cohort. Materials and Methods: We analyzed annual caseload temporal trends in 34,803 patients who underwent surgery between 1999 and 2008 in Florida. Logistic regression models controlled for clustering among surgeons addressed the relationship of surgical experience, defined as the number of radical prostatectomies done since January 1, 1999 until each radical prostatectomy, with complications and transfusions. Results: During the study period the proportion of surgeons in the high annual caseload tertile (24 radical prostatectomies or greater yearly) and the proportion of patients treated by those surgeons increased from 5% to 10% and from 20% to 55%, respectively. Conversely complication and transfusion rates decreased from 14.3% to 9.2% and 12.6% to 6.9%, respectively. Radical prostatectomies done by surgeons in the high surgical experience tertile (86 or greater radical prostatectomies) decreased the risk of any complication by 33% and of any transfusion by 30% vs those in patients operated on by surgeons in the low surgical experience tertile (27 or fewer radical prostatectomies). Conclusions: The proportion of surgeons in the high annual caseload tertile and the proportion of patients treated by these surgeons steadily increased during the last decade. Complication and transfusion rates decreased with time. The implications of these encouraging findings may result in improved outcomes in patients with surgically managed prostate cancer.
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- 2010
9. Location of the primary tumor is not an independent predictor of cancer specific mortality in patients with upper urinary tract urothelial carcinoma
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Pierre I. Karakiewicz, Philippe Arjane, Hendrik Isbarn, Maxine Sun, Shahrokh F. Shariat, Margit Fisch, Paul Perrotte, Daniel Pharand, Hugues Widmer, Francesco Montorsi, Markus Graefen, Giovanni Lughezzani, Daniel Liberman, Claudio Jeldres, Isbarn, Hendrik, Jeldres, Claudio, Shariat Shahrokh, F., Liberman, Daniel, Sun, Maxine, Lughezzani, Giovanni, Widmer, Hugue, Arjane, Philippe, Pharand, Daniel, Fisch, Margit, Graefen, Marku, Montorsi, Francesco, Perrotte, Paul, and Karakiewicz Pierre, I.
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Adult ,Male ,medicine.medical_specialty ,Urology ,Urinary system ,Ureter ,medicine ,Carcinoma ,Humans ,Kidney Pelvis ,Upper urinary tract ,Aged ,Retrospective Studies ,Aged, 80 and over ,Carcinoma, Transitional Cell ,business.industry ,Ureteral Neoplasms ,Cancer ,Middle Aged ,medicine.disease ,Prognosis ,Primary tumor ,Kidney Neoplasms ,medicine.anatomical_structure ,Transitional cell carcinoma ,Female ,business ,Renal pelvis - Abstract
Purpose: The prognostic significance of renal pelvis vs ureteral upper urinary tract urothelial carcinoma tumor location is controversial. We assessed the prognostic significance of upper urinary tract urothelial carcinoma tumor location in a large, population based data set. Materials and Methods: Our analyses relied on 2,824 patients treated with nephroureterectomy for upper urinary tract urothelial carcinoma within 9 SEER registries between 1988 and 2004. Univariable and multivariable models tested the effect of tumor location on cancer specific mortality rates. Covariates consisted of age, race, SEER registry, gender, type of surgery (nephroureterectomy with vs without bladder cuff removal), pT stage, pN stage, grade and year of surgery. Results: Relative to ureteral tumors renal pelvis tumors were of higher stage (T3/T4 disease 38.4% vs 57.9%, p
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- 2009
10. Development and external validation of a highly accurate nomogram for the prediction of perioperative mortality after transurethral resection of the prostate for benign prostatic hyperplasia
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Martine Jolivet-Tremblay, Claudio Jeldres, Francesco Montorsi, Paul Perrotte, Laurent Zini, Shahrokh F. Shariat, Fred Saad, Naeem Bhojani, Pierre I. Karakiewicz, Umberto Capitanio, Alain Duclos, Hendrik Isbarn, Jean Baptiste Lattouf, Luc Valiquette, Markus Graefen, Vincent Cloutier, Jeldres, Claudio, Isbarn, Hendrik, Capitanio, Umberto, Zini, Laurent, Bhojani, Naeem, Shariat Shahrokh, F., Cloutier, Vincent, Lattouf Jean, Baptiste, Duclos, Alain, Jolivet Tremblay, Martine, Valiquette, Luc, Saad, Fred, Graefen, Marku, Montorsi, Francesco, Perrotte, Paul, and Karakiewicz Pierre, I.
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Urology ,medicine.medical_treatment ,Prostatic Hyperplasia ,Prostate ,Predictive Value of Tests ,Epidemiology ,medicine ,Humans ,Transurethral resection of the prostate ,Aged ,Aged, 80 and over ,business.industry ,Mortality rate ,Transurethral Resection of Prostate ,Reproducibility of Results ,Perioperative ,Nomogram ,Hyperplasia ,Middle Aged ,medicine.disease ,Surgery ,Nomograms ,Urethra ,medicine.anatomical_structure ,business - Abstract
Purpose: Benign prostatic hyperplasia affects 60% of men at the age of 60 years. Transurethral resection of the prostate is the gold standard of therapy. We assessed the 30-day mortality rate after transurethral resection of the prostate for benign prostatic hyperplasia, identified risk factors related to 30-day mortality and developed a model that discriminates among individual 30-day mortality risk levels. Materials and Methods: We performed development (7,362) and external validation (7,362) of a multivariable logistic regression model predicting the individual probability of 30-day mortality after transurethral resection of the prostate based on an administrative data set (Quebec Health Plan) of 14,724 patients 43 to 99 years old treated between January 1, 1989 and December 31, 2000. Results: Overall 30-day mortality occurred in 58 patients (0.4%) undergoing transurethral resection of the prostate. On univariable analyses increasing age (p
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- 2008
11. Nomogram for predicting disease recurrence after radical cystectomy for transitional cell carcinoma of the bladder
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Amit Gupta, Pierre I. Karakiewicz, Ganesh S. Palapattu, Amnon Vazina, Shahrokh F. Shariat, Mark P. Schoenberg, Craig G. Rogers, Yair Lotan, Amiel Gilad, Patrick J. Bastian, Arthur I. Sagalowsky, Paul Perrotte, and Seth P. Lerner
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Adult ,Male ,medicine.medical_specialty ,Lymphovascular invasion ,Urology ,medicine.medical_treatment ,Cystectomy ,Pelvis ,Cohort Studies ,Predictive Value of Tests ,Bladder Neoplasm ,medicine ,Carcinoma ,Humans ,Cancer staging ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,Carcinoma, Transitional Cell ,Bladder cancer ,business.industry ,Carcinoma in situ ,Middle Aged ,medicine.disease ,Surgery ,Nomograms ,Transitional cell carcinoma ,Treatment Outcome ,Urinary Bladder Neoplasms ,Lymph Node Excision ,Female ,Neoplasm Recurrence, Local ,business - Abstract
American Joint Committee on Cancer staging represents the gold standard for prediction of recurrence after radical cystectomy in patients with invasive bladder cancer. We tested the hypothesis that American Joint Committee on Cancer stage based predictions may be improved when pathological tumor and node stage information is combined with additional clinical and pathological variables within a prognostic nomogram.We used Cox proportional hazards regression analysis to model variables of 728 patients with transitional cell carcinoma of the bladder treated with radical cystectomy and bilateral pelvic lymphadenectomy at 1 of 3 participating institutions. Standard predictors, pT and pN, were complemented by age, gender, tumor grade at cystectomy, presence of lymphovascular invasion, presence of carcinoma in situ in the cystectomy specimen, neoadjuvant chemotherapy, adjuvant chemotherapy and adjuvant radiotherapy. The concordance index was used to quantify the accuracy of regression coefficient based nomograms. A total of 200 bootstrap resamples were used to reduce overfit bias and for internal validation. Calibration plots were used to graphically explore the performance characteristics of the multivariate nomogram.Followup ranged from 0.1 to 183.4 months (median 24.9, mean 36.4). Recurrence was recorded in 249 (34.2%) patients with a median time to recurrence of 108 months (range 0.8 to 131.9). Actuarial recurrence-free probabilities were 69.6% (95% CI 65.8%-73.0%), 60.2% (55.8%-64.3%) and 52.9% (47.3%-58.1%) at 2, 5 and 8 years after cystectomy, respectively. Two-hundred bootstrap corrected predictive accuracy of American Joint Committee on Cancer stage based predictions was 0.748. Accuracy increased by 3.2% (0.780) when age, lymphovascular invasion, carcinoma in situ, neoadjuvant chemotherapy, adjuvant chemotherapy and adjuvant radiotherapy were added to pathological stage information and used within a nomogram.A nomogram predicting bladder cancer recurrence after cystectomy is 3.2% more accurate than American Joint Committee on Cancer stage based predictions. Moreover, a nomogram approach combines several advantages such as easy and precise estimation of individual recurrence probability at key points after cystectomy, which all patients deserve to know and all treating physicians need to know.
- Published
- 2005
12. A POPULATION-BASED ASSESSMENT OF PERIOPERATIVE MORTALITY AFTER CYSTECTOMY FOR BLADDER CANCER
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Hendrik Isbarn, Laurent Zini, Sara Baillargeon Gagne, Paul Perrotte, Claudio Jeldres, Umberto Capitanio, Shahrokh Shariat, Philippe Arjane, Fred Saad, Michael McCormack, Luc Valiquette, Francois Peloquin, Alain Duclos, Francesco Montorsi, Markus Graefen, and Pierre Karakiewicz
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Urology - Published
- 2009
13. GENDER IS AN IMPORTANT PREDICTOR OF CANCER-SPECIFIC SURVIVAL IN PATIENT WITH TRANSITIONAL CELL CARCINOMA AFTER RADICAL CYSTECTOMY
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Shahrokh F. Shariat, Pierre I. Karakiewicz, Sara Baillargeon-Gagne, Naeem Bhojani, Paul Perrotte, Claudio Jeldres, Hendrik Isbarn, Francesco Montorsi, Fred Saad, Umberto Capitanio, Nazareno Suardi, and Andrea Gallina
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Oncology ,medicine.medical_specialty ,business.industry ,Urology ,medicine.medical_treatment ,medicine.disease ,Cancer specific survival ,Cystectomy ,Transitional cell carcinoma ,Internal medicine ,Medicine ,In patient ,business - Published
- 2009
14. THE EFFECT OF ORGAN SITE ON SURVIVAL AFTER RESECTION OF A SOLITARY RENAL CELL CARCINOMA (RCC) METASTASIS
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Joel W. Slaton, Colin P.N. Dinney, Julie A. Ellerhorst, Paul Perrotte, and David A. Swanson
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medicine.medical_specialty ,business.industry ,Renal cell carcinoma ,Urology ,Medicine ,business ,medicine.disease ,Metastasis ,Resection - Published
- 1999
15. SALVAGE CRYOTHERAPY FOR RECURRENT PROSTATE CANCER FOLLOWING RADIATION THERAPY
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Edward J. McGuire, O. Lenaine Westney, Louis L. Pisters, Paul Perrotte, Jean Paul Tran, Shellie M. Scott, Andrew C. von Eschenbach, and Graham F. Greene
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Oncology ,Radiation therapy ,medicine.medical_specialty ,Prior Therapy ,business.industry ,Urology ,medicine.medical_treatment ,Internal medicine ,medicine ,Recurrent prostate cancer ,Patient survival ,Cryotherapy ,business - Published
- 1999
16. INTRALESIONAL INTERFERON GENE TRANSFER INHIBITS THE GROWTH OF HUMAN TRANSITIONAL CELL CARCINOMA (TCC) GROWING IN ATHYMIC NUDE MICE BY INHIBITION OF ANGIOGENESIS AND ACTIVATION OF MACROPHAGES
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Colin P.N. Dinney, Keiji Inoue, Joel W. Slaton, Beryl Y. Eve, and Paul Perrotte
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Transitional cell carcinoma ,Interferon ,Angiogenesis ,business.industry ,Urology ,medicine ,Cancer research ,Gene transfer ,medicine.disease ,business ,medicine.drug - Published
- 1999
17. INTERLEUKIN-8 (IL-8) EXPRESSION REGULATES METASTASIS IN ANDROGEN-INDEPENDENT PROSTATE CANCER
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Joel W. Slaton, Paul Perrotte, Beryl Y. Eve, Colin P.N. Dinney, Keiji Inoue, Curtis A. Pettaway, and M. Derya Balbay
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PCA3 ,Oncology ,medicine.medical_specialty ,Androgen independent prostate cancer ,business.industry ,Urology ,Internal medicine ,medicine ,Interleukin 8 ,medicine.disease ,business ,Metastasis - Published
- 1999
18. RATIO OF MATRIX METALLOPROTEASES (MMP) TO E-CADHERIN (ECAD) EXPRESSION IS AN INDEPENDENT PREDICTOR OF METASTASIS IN RENAL CELL CARCINOMA (RCC)
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Colin P.N. Dinney, Adel K. El-Naggar, Keiji Inoue, Paul Perrotte, Joel W. Slaton, David A. Swanson, and Isaiah J. Fidler
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Cadherin ,Renal cell carcinoma ,business.industry ,Urology ,Matrix metalloproteases ,Cancer research ,medicine ,Matrix metalloproteinase ,Independent predictor ,medicine.disease ,business ,Metastasis - Published
- 1999
19. SALVAGE CRYOTHERAPY FOR RECURRENT PROSTATE CANCER FOLLOWING RADIATION THERAPY
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Graham F. Greene, Andrew C. von Eschenbach, Shellie M. Scott, Jean Paul Tran, Louis L. Pisters, and Paul Perrotte
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Oncology ,Radiation therapy ,medicine.medical_specialty ,business.industry ,Urology ,Internal medicine ,medicine.medical_treatment ,medicine ,Recurrent prostate cancer ,Cryotherapy ,business ,Tumor control - Published
- 1999
20. BASIC FIBROBLAST GROWTH FACTOR IS A TARGET FOR GENE THERAPY IN TRANSITIONAL CELL CARCINOMA (TCC) OF THE BLADDER
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Christopher G. Wood, Colin P.N. Dinney, Joel W. Slaton, Keiji Inoue, and Paul Perrotte
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chemistry.chemical_compound ,Transitional cell carcinoma ,chemistry ,business.industry ,Urology ,Genetic enhancement ,Basic fibroblast growth factor ,Cancer research ,Medicine ,business ,medicine.disease - Published
- 1999
21. INTERLEUKIN-8 (IL-8) EXPRESSION REGULATES TUMORIGENICITY AND METASTASIS IN HUMAN BLADDER CANCER
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Colin P.N. Dinney, Paul Perrotte, Beryl Y. Eve, Keiji Inoue, and Joel W. Slaton
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Oncology ,medicine.medical_specialty ,business.industry ,Urology ,Internal medicine ,Human bladder ,medicine ,Cancer ,Interleukin 8 ,medicine.disease ,business ,Metastasis - Published
- 1999
22. THE PROGNOSTIC SIGNIFICANCE OF ANGIOGENIC FACTOR EXPRESSION IN RENAL CELL CARCINOMA (RCC)
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Adel K. El-Naggar, David A. Swanson, Paul Perrotte, Isaiah J. Fidler, Colin P.N. Dinney, Keiji Inoue, and Joel W. Slaton
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Oncology ,medicine.medical_specialty ,business.industry ,Renal cell carcinoma ,Urology ,Internal medicine ,medicine ,business ,medicine.disease - Published
- 1999
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