1. Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study
- Author
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Steven W. Boyce, Roberto Bolli, Andreas Jessel, Eric Chi, John C. Chen, Bernard R. Chaitman, Claus Bartels, Dean J. Kereiakes, Lars I. Thulin, John L. Knight, and Pierre Theroux
- Subjects
Male ,Time Factors ,medicine.medical_treatment ,Myocardial Infarction ,Guanidines ,Severity of Illness Index ,Cohort Studies ,Angina ,chemistry.chemical_compound ,Postoperative Complications ,Risk Factors ,Cause of Death ,Creatine Kinase, MB Form ,Sulfones ,Myocardial infarction ,Angioplasty, Balloon, Coronary ,Coronary Artery Bypass ,Infusions, Intravenous ,Creatine Kinase ,education.field_of_study ,Ejection fraction ,Incidence ,Middle Aged ,Europe ,Isoenzymes ,Treatment Outcome ,Anesthesia ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Anti-Arrhythmia Agents ,Adult ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Sodium-Hydrogen Exchangers ,Adolescent ,Population ,Placebo ,Double-Blind Method ,Angioplasty ,Internal medicine ,medicine ,Humans ,Angina, Unstable ,education ,Aged ,Dose-Response Relationship, Drug ,Cariporide ,business.industry ,Unstable angina ,medicine.disease ,Survival Analysis ,Death, Sudden, Cardiac ,chemistry ,North America ,Surgery ,business ,Risk Reduction Behavior ,Follow-Up Studies - Abstract
Objectives: To evaluate the effects of cariporide on all-cause mortality or myocardial infarction at 36 days in patients at risk,of myocardial necrosis after coronary artery bypass graft surgery. Methods: In the coronary artery bypass graft cohort of the GUARD During Ischemia Against Necrosis trial, patients greater than or equal to 18 years who required urgent coronary artery bypass graft, repeat coronary artery bypass graft, or had a history of unstable angina and 2 :2 risk factors (age >65 years, female gender, diabetes mellitus, ejection fraction
- Published
- 2003
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