1. Impact of early positive cultures in the elderly with traumatic brain injury
- Author
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Gretchen M. Thomsen, Ara Ko, Eric J.T. Smith, Navpreet K. Dhillon, Joshua Tseng, Galinos Barmparas, Megan Y. Harada, and Eric J. Ley
- Subjects
Male ,medicine.medical_specialty ,Bacteriuria ,Traumatic brain injury ,Population ,Bacteremia ,law.invention ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,law ,Internal medicine ,Brain Injuries, Traumatic ,medicine ,Risk of mortality ,Humans ,education ,Aged ,Retrospective Studies ,Aged, 80 and over ,education.field_of_study ,business.industry ,Hazard ratio ,Sputum ,030208 emergency & critical care medicine ,Retrospective cohort study ,Length of Stay ,medicine.disease ,Intensive care unit ,Intensive Care Units ,Surgery ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
BACKGROUND Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in the United States, especially in the elderly, who have the highest rates of TBI-related hospitalizations and deaths among all age groups. Sepsis is one of many risk factors that is associated with higher mortality and longer length of hospital stay in this population partially due to the immunosuppressive effects of TBI. The significance of early indicators of infection, such as a positive blood, sputum, or urine culture, is not well described. The purpose of this study was to determine if early positive cultures predict higher mortality in elderly patients with TBI. METHODS All trauma patients aged ≥65 years with TBI, admitted between January 1, 2009 and December 31, 2013 to the surgical intensive care unit, were retrospectively reviewed. Clinical data including results from sputum, blood, and urine cultures were reviewed. RESULTS Overall, 288 elderly patients with TBI were identified, and 92 (32%) had a positive culture. Patients with positive cultures had longer intensive care unit (median 6.0 versus 2.0 days, P
- Published
- 2017