1. Effect of length of controlled ovarian hyperstimulation using a gonadotropin-releasing hormone antagonist on in vitro fertilization pregnancy rates
- Author
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G Donald, Royster, Matthew G, Retzloff, Randal D, Robinson, Jeremy A, King, and Anthony M, Propst
- Subjects
Adult ,Pregnancy Rate ,Oocyte Retrieval ,Fertilization in Vitro ,Chorionic Gonadotropin ,Cohort Studies ,Gonadotropin-Releasing Hormone ,Hormone Antagonists ,Ovarian Follicle ,Ovulation Induction ,Pregnancy ,Humans ,Reproductive Control Agents ,Female ,Sperm Injections, Intracytoplasmic ,Live Birth ,Retrospective Studies - Abstract
To compare pregnancy outcomes between shorter and longer in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles using GnRH antagonist protocol.Retrospective cohort analysis at a large military academic hospital. A total of 351 patients underwent 412 IVF/ICSI cycles using a GnRH antagonist protocol from September 2002 through May 2008. Clinical pregnancy and live birth rates for all IVF/ICSI cycles were compared independently for both total length of ovarian stimulation with gonadotropins (10 days vs.or = 10 days) and GnRH antagonist use (4 days vs.or = 4 days), respectively.Clinical pregnancy rates were 54.6% among cycles with total gonadotropin use10 days vs. 48.6% for those cyclesor = 10 days, odds ratio 0.82 (0.53-1.27); live birth rates were 50.0% vs. 47.7%, odds ratio 0.91 (0.59-1.42). Clinical pregnancy rates were 54.0% among cycles with GnRH antagonist use4 days vs. 52.8% with GnRH antagonist useor = 4 days, odds ratio 0.95 (0.62-1.45); live birth rates were 46.8% vs. 50.4%, odds ratio 1.15 (0.76-1.76).Clinical pregnancy and live birth rates are not adversely affected by longer IVF/ICSI cycles using GnRH antagonists.
- Published
- 2012