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Your search keyword '"Yeji Wang"' showing total 2 results
Start Over Author "Yeji Wang" Journal the journal of organic chemistry
2 results on '"Yeji Wang"'

1. Discovery of a DNA Topoisomerase I Inhibitor Huanglongmycin N and Its Congeners from Streptomyces sp. CB09001

Author

Saibin Zhu, Zhongqing Wen, Yong Huang, Yeji Wang, and Yanwen Duan

Subjects
biology, Chemistry, Stereochemistry, Organic Chemistry, Topoisomerase-I Inhibitor, biology.organism_classification, Streptomyces, Pyrone, chemistry.chemical_compound, Pyran, Cancer cell, A-DNA, Ethyl group, Cytotoxicity
Abstract

Huanglongmycin (HLM) congeners G-N (7-14) were isolated from Streptomyces sp. CB09001. Among them, 10-12 possesses a tricyclic scaffold with benzene-fused pyran/pyrone, confirmed by X-ray single crystal diffraction analysis of 12. The structure-activity relationship study of 1, 13, and 14 revealed not only the stronger cytotoxicity of 14 against tested cancer cells but also the critical role of the C-7 ethyl group of 14 in its binding to the DNA-topoisomerase I complex.

Published
2021
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