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Start Over Author "Jeffrey A. Stafford" Journal the journal of organic chemistry
5 results on '"Jeffrey A. Stafford"'

4. Efficient and regioselective synthesis of 2-alkyl-2H-indazoles

Author

Jeffrey A. Stafford, Amogh Boloor, and Mui Cheung

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Hexafluorophosphate, Organic Chemistry, Trimethyloxonium tetrafluoroborate, Organic chemistry, Regioselectivity, General Medicine, Alkylation, Medicinal chemistry, Chemical synthesis, Alkyl
Abstract

An efficient and regioselective synthesis of 2-methyl-2H-indazoles and 2-ethyl-2H-indazoles using trimethyloxonium tetrafluoroborate or triethyloxonium hexafluorophosphate is reported.

Published
2003

5. Daphniphyllum alkaloids. Part 8. Asymmetric total synthesis of (-)-secodaphniphylline

Author

Jeffrey A. Stafford and Clayton H. Heathcock

Subjects
biology, Stereochemistry, Organic Chemistry, Acetal, Enantioselective synthesis, Total synthesis, biology.organism_classification, chemistry.chemical_compound, chemistry, Amide, Michael reaction, Enantiomer, Chirality (chemistry), Daphniphyllum
Abstract

(-)-Secodaphniphylline (1) has been prepared by total synthesis. The early stages,of the synthesis were an asymmetric version of the previously published synthesis of methyl homosecodaphniphyllate (2). The necessary chirality was secured by an asymmetric Michael addition reaction of the lithium enolate of the C 2 -symmetric amide 9 to α,β-unsaturated ester 10 to give ester amide 12. The conversion of 12 into (-)-2 was modelled after the previously reported synthesis in the analogous racemic series

Published
1990

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