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Start Over Author "Dong-Po Jin" Journal the journal of organic chemistry
1 results on '"Dong-Po Jin"'

1. Electrophilic Cyclization of Aryl Propargylic Alcohols: Synthesis of Dihalogenated 6,9-Dihydropyrido[1,2-a]indoles via a Cascade Iodocyclization

Author

Jia Wang, Yong-Min Liang, Hai-Tao Zhu, Dong-Po Jin, Ying-Xiu Li, Yi-Feng Qiu, Yu Xia, and Si Chen

Subjects
010405 organic chemistry, Aryl, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Coupling reaction, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Cascade, Yield (chemistry), Functional group, Electrophile, Organic chemistry
Abstract

A strategy for the synthesis of 6,9-dihydropyrido[1,2-a]indoles through a cascade iodocyclization of 4-(3-methyl-1H-indol-1-yl)-1,1-diphenylbut-2-yn-1-ol derivatives is presented. This reaction was conducted under very mild conditions and in a short time. The reactions are metal-free, are environmentally friendly and give up to 94% yield. Moreover, the obtained halides allow functional group diversification by palladium-catalyzed coupling reactions, which could act as potential intermediates for the synthesis of valuable compounds.

Published
2016

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