1. Parabrachial Complex: A Hub for Pain and Aversion
- Author
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Michael C. Chiang, Anna J Bowen, Lindsey A. Schier, Olivia Uddin, Mary M. Heinricher, Domenico Tupone, Chiang M.C., Bowen A., Schier L.A., Tupone D., Uddin O., and Heinricher M.M.
- Subjects
0301 basic medicine ,Taste ,Pain ,Context (language use) ,Sensory system ,brainstem ,taste ,03 medical and health sciences ,0302 clinical medicine ,Neural Pathways ,medicine ,Animals ,Humans ,nociception ,alarm ,Neurons ,thermoregulation ,Parabrachial Nucleus ,General Neuroscience ,Symposium and Mini-Symposium ,Thermoregulation ,medicine.disease ,Physiological responses ,defense ,030104 developmental biology ,Nociception ,Psychology ,Neuroscience ,030217 neurology & neurosurgery ,Ingestive behaviors ,Body Temperature Regulation - Abstract
The parabrachial nucleus (PBN) has long been recognized as a sensory relay receiving an array of interoceptive and exteroceptive inputs relevant to taste and ingestive behavior, pain, and multiple aspects of autonomic control, including respiration, blood pressure, water balance, and thermoregulation. Outputs are known to be similarly widespread and complex. How sensory information is handled in PBN and used to inform different outputs to maintain homeostasis and promote survival is only now being elucidated. With a focus on taste and ingestive behaviors, pain, and thermoregulation, this review is intended to provide a context for analysis of PBN circuits involved in aversion and avoidance, and consider how information of various modalities, interoceptive and exteroceptive, is processed within PBN and transmitted to distinct targets to signal challenge, and to engage appropriate behavioral and physiological responses to maintain homeostasis.
- Published
- 2019
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