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Your search keyword '"Mansukhani, Mahesh"' showing total 7 results
Start Over Author "Mansukhani, Mahesh" Journal the journal of molecular diagnostics
7 results on '"Mansukhani, Mahesh"'

3. Multi-Institutional Evaluation of Interrater Agreement of Variant Classification Based on the 2017 Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer

Author

Sirohi, Deepika, primary, Schmidt, Robert L., additional, Aisner, Dara L., additional, Behdad, Amir, additional, Betz, Bryan L., additional, Brown, Noah, additional, Coleman, Joshua F., additional, Corless, Christopher L., additional, Deftereos, Georgios, additional, Ewalt, Mark D., additional, Fernandes, Helen, additional, Hsiao, Susan J., additional, Mansukhani, Mahesh M., additional, Murray, Sarah S., additional, Niu, Nifang, additional, Ritterhouse, Lauren L., additional, Suarez, Carlos J., additional, Tafe, Laura J., additional, Thorson, John A., additional, Segal, Jeremy P., additional, and Furtado, Larissa V., additional

Published
2020
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4. Analytical Validation of Clinical Whole-Genome and Transcriptome Sequencing of Patient-Derived Tumors for Reporting Targetable Variants in Cancer

Author

Wrzeszczynski, Kazimierz O., primary, Felice, Vanessa, additional, Abhyankar, Avinash, additional, Kozon, Lukasz, additional, Geiger, Heather, additional, Manaa, Dina, additional, London, Ferrah, additional, Robinson, Dino, additional, Fang, Xiaolan, additional, Lin, David, additional, Lamendola-Essel, Michelle F., additional, Khaira, Depinder, additional, Dikoglu, Esra, additional, Emde, Anne-Katrin, additional, Robine, Nicolas, additional, Shah, Minita, additional, Arora, Kanika, additional, Basturk, Olca, additional, Bhanot, Umesh, additional, Kentsis, Alex, additional, Mansukhani, Mahesh M., additional, Bhagat, Govind, additional, and Jobanputra, Vaidehi, additional

Published
2018
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7. Evaluation of a Zoonotic OrthopoxvirusPCR Assay for the Detection of Monkeypox Virus Infection

Author

Velu, Priya, Sipley, John, Marino, Jamie, Ghanshani, Sanjiv, Lukose, Georgi, Cong, Lin, Serrano, Liliana, Ly, Thanh, Yeh, Raymond K., Wu, Fan, Mansukhani, Mahesh, Berry, Greg, and Rennert, Hanna

Abstract

An epidemic caused by an outbreak of monkeypox (mpox) in May 2022 rapidly spread internationally, requiring an urgent response from the clinical diagnostics community. A detailed description of the clinical validation and implementation of a laboratory-developed real-time PCR test for detecting nonvariola Orthopoxvirus-specific DNA based on the newly designed RealStar Zoonotic Orthopoxvirus assay is presented. The validation was performed using an accuracy panel (n = 97) comprising skin lesion swabs in universal transport media and from mpox virus genomic DNA spiked into pooled mpox virus–negative remnant universal transport media of lesion specimens submitted for routine clinical testing in the NewYork-Presbyterian Hospital clinical laboratory system. Accuracy testing demonstrated excellent assay agreement between expected and observed values and comparable diagnostic performance to three different reference tests. Analytical sensitivity with 95% detection probability was 126 copies/mL, and analytical specificity, clinical sensitivity, and clinical specificity were 100%. In summary, the RealStar Zoonotic Orthopoxvirus assay provides a sensitive and reliable method for routine diagnosis of mpox infections.

Published
2023
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