1. Multiple drug-resistant Chlamydia trachomatis associated with clinical treatment failure
- Author
-
Jyoti Somani, Carol E. Farshy, Carolyn M. Black, Kimberly A. Workowski, and Vinod Bhullar
- Subjects
Male ,Ofloxacin ,Adolescent ,medicine.drug_class ,Antibiotics ,Chlamydia trachomatis ,Drug resistance ,Microbial Sensitivity Tests ,Azithromycin ,medicine.disease_cause ,Anti-Infective Agents ,Pregnancy ,medicine ,Disease Transmission, Infectious ,Immunology and Allergy ,Humans ,Chlamydiaceae ,Urethritis ,Pregnancy Complications, Infectious ,Antibacterial agent ,Doxycycline ,biology ,Chlamydia Infections ,biology.organism_classification ,medicine.disease ,Drug Resistance, Multiple ,Anti-Bacterial Agents ,Infectious Diseases ,Immunology ,Female ,medicine.drug - Abstract
In vitro susceptibility testing and genotyping were done on urogenital isolates of Chlamydia trachomatis from 3 patients, 2 of whom showed evidence of clinical treatment failure with azithromycin and one of whom was the wife of a patient. All 3 isolates demonstrated multidrug resistance to doxycycline, azithromycin, and ofloxacin at concentrations >4.0 microg/mL. Recurrent disease due to relapsing infection with the same resistant isolate was documented on the basis of identical genotypes of both organisms. This first report of clinically significant multidrug-resistant C. trachomatis causing relapsing or persistent infection may portend an emerging problem to clinicians and public health officials.
- Published
- 1999