1. Transmission of a newly characterized strain of varicella-zoster virus from a patient with herpes zoster in a long-term-care facility, West Virginia, 2004
- Author
-
Ram Nambiar, Andrea N. Burnett-Hartman, D. Scott Schmid, Dalya Guris, Linda Ritz, Patricia Owens, Vladimir N. Loparev, and Adriana S. Lopez
- Subjects
Adult ,Male ,Herpesvirus 3, Human ,Infectious Disease Transmission, Patient-to-Professional ,Genotype ,viruses ,medicine.disease_cause ,Antiviral Agents ,Herpes Zoster ,Herpesviridae ,Virus ,Article ,Disease Outbreaks ,Chickenpox Vaccine ,Chickenpox ,Alphaherpesvirinae ,Immunology and Allergy ,Medicine ,Humans ,Phylogeny ,Aged, 80 and over ,Cross Infection ,biology ,integumentary system ,business.industry ,Varicella zoster virus ,Outbreak ,virus diseases ,biochemical phenomena, metabolism, and nutrition ,Middle Aged ,West Virginia ,medicine.disease ,biology.organism_classification ,Virology ,Long-Term Care ,eye diseases ,Infectious Diseases ,Fomites ,Immunology ,DNA, Viral ,Female ,Viral disease ,business - Abstract
We investigated a small outbreak of varicella in a long-term-care facility after a case of herpes zoster. Clinical specimens and environmental samples were collected from all case patients and from surfaces in the case patients' rooms and other common-use areas. Wild-type varicella-zoster virus (VZV) DNA was identified in all 3 varicella case patients, and high concentrations of VZV DNA were detected in environmental samples from the room of the herpes zoster case patient. Genotypic analysis showed that the identical VZV strain was present in all samples; moreover, the strain was a unique Mosaic genotype isolate that included a stable Oka vaccine marker that had hitherto never been observed in a wild-type strain of VZV. This study provides evidence for the value of including environmental sampling during the investigation of varicella outbreaks and illustrates the importance of evaluating multiple vaccine-associated markers for the discrimination of vaccine virus from wild-type VZV.
- Published
- 2008