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Your search keyword '"Martha T. van der Beek"' showing total 2 results
Start Over Author "Martha T. van der Beek" Journal the journal of infectious diseases
2 results on '"Martha T. van der Beek"'

1. New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections

Author

Alex Loukas, Mikhael D Manurung, Luc E. Coffeng, Leo G. Visser, Eric A. T. Brienen, Chelsea Gootjes, Sake J. de Vlas, Munisha S. Ganesh, C. Feijt, Marie-Astrid Hoogerwerf, Jacqueline J. Janse, Pauline Meij, Yvonne C. M. Kruize, Marijke C. C. Langenberg, Martha T. van der Beek, Marianne A A Erkens, Mark Dekker, Meta Roestenberg, Luke Becker, Inge M Westra, Maria Yazdanbakhsh, Beatrice M. F. Winkel, Lisette van Lieshout, and Public Health

Subjects
0301 basic medicine, Male, Veterinary medicine, Necator americanus, Bayesian statistics, Models, Biological, Excretion, Necatoriasis, 03 medical and health sciences, Feces, Young Adult, 0302 clinical medicine, parasitic diseases, Immunology and Allergy, Helminths, Animals, Humans, 030212 general & internal medicine, Hookworm infection, Larva, biology, Bayes Theorem, Vaccine efficacy, biology.organism_classification, Healthy Volunteers, Blood Cell Count, Eosinophils, Kinetics, 030104 developmental biology, Infectious Diseases, vaccine development, Hookworm Infections, controlled human infection, Female, hookworm, Follow-Up Studies
Abstract

Four healthy volunteers were infected with 50 Necator americanus infective larvae (L3) in a controlled human hookworm infection trial and followed for 52 weeks. The kinetics of fecal egg counts in volunteers was assessed with Bayesian multilevel analysis, which revealed an increase between weeks 7 and 13, followed by an egg density plateau of about 1000 eggs/g of feces. Variation in egg counts was minimal between same-day measurements but varied considerably between days, particularly during the plateau phase. These analyses pave the way for the controlled human hookworm model to accelerate drug and vaccine efficacy studies.

Published
2019

2. Establishing the Production of Male Schistosoma mansoni Cercariae for a Controlled Human Infection Model

Author

Hermelijn H. Smits, Arifa Ozir-Fazalalikhan, Leo G. Visser, Martha T. van der Beek, Meta Roestenberg, Beatrice M. F. Winkel, Angela van Diepen, Marianne A A Erkens, Jacqueline J. Janse, Cornelis H. Hokke, Janneke Kos-van Oosterhoud, Richard Verbeek, Lisette van Lieshout, Eric A. T. Brienen, Inge M Westra, Maria Yazdanbakhsh, Bonnie L. Webster, Maarten L. Zandvliet, Pauline Meij, and Marijke C. C. Langenberg

Subjects
0301 basic medicine, Male, 030231 tropical medicine, Snails, Schistosomiasis, Snail, Biology, Biomphalaria glabrata, Food and drug administration, 03 medical and health sciences, 0302 clinical medicine, biology.animal, vaccine, parasitic diseases, Healthy volunteers, medicine, Immunology and Allergy, media_common.cataloged_instance, Animals, Humans, Good manufacturing practice, European union, Cercaria, media_common, human challenge model, cercariae, Schistosoma mansoni, biology.organism_classification, medicine.disease, Schistosomiasis mansoni, 030104 developmental biology, Infectious Diseases, Immunology, controlled human infection model
Abstract

To accelerate the development of novel vaccines for schistosomiasis, we set out to develop a human model for Schistosoma mansoni infection in healthy volunteers. During natural infections, female schistosomes produce eggs that give rise to morbidity. Therefore, we produced single-sex, male Schistosoma mansoni cercariae for human infection without egg production and associated pathology. Cercariae were produced in their intermediate snail hosts in accordance with the principles of good manufacturing practice (GMP). The application of GMP principles to an unconventional production process is a showcase for the controlled production of complex live challenge material in the European Union or under Food and Drug Administration guidance.

Published
2018

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