1. Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease
- Author
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David Ferguson, Richard A. Martinello, Marie L. Landry, Carla Weibel, Frank Esper, and Jeffrey S. Kahn
- Subjects
Microbiology (medical) ,Male ,medicine.medical_specialty ,Exacerbation ,viruses ,Article ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Hospitals, Urban ,Human metapneumovirus ,Paramyxoviridae infection ,Internal medicine ,Medicine ,Humans ,Metapneumovirus ,030212 general & internal medicine ,Hospitals, Teaching ,Phylogeny ,Aged ,Aged, 80 and over ,COPD ,Paramyxoviridae Infections ,biology ,Respiratory tract infections ,business.industry ,Viral culture ,Reverse Transcriptase Polymerase Chain Reaction ,Respiratory disease ,virus diseases ,Obstructive lung disease ,Middle Aged ,medicine.disease ,biology.organism_classification ,3. Good health ,respiratory tract diseases ,Hospitalization ,Connecticut ,Infectious Diseases ,030228 respiratory system ,Lung disease ,Immunology ,Female ,business - Abstract
Summary Objective Respiratory viruses are a common trigger for exacerbations of chronic obstructive pulmonary disease (COPD). Human metapneumovirus (hMPV) is a paramyxovirus associated with respiratory tract infections and wheezing. Our aim was to determine whether hMPV was associated with exacerbations of COPD. Methods The study was designed as an observational cohort study carried out in a 944-bed urban teaching hospital located in New Haven, Connecticut. Between December 2002 and May 2003, patients hospitalized due to an exacerbation of COPD were identified. Nasopharyngeal specimens obtained from these patients were tested for human metapneumovirus by RT–PCR and for respiratory syncytial virus, influenza A and B, parainfluenza-1, -2, and -3 and adenovirus by a cytospin-enhanced direct immunofluorescence assay and/or viral culture. Results Fifty individuals met enrollment criteria and hMPV was identified in 6 (12%), respiratory syncytial virus in 4 (8%), influenza A in 2 (4%) and parainfluenza type 3 in 1 (2%) patients. Both A and B hMPV genotypes were identified in patients hospitalized due to exacerbations of COPD. Conclusion hMPV was frequently identified in patients hospitalized due to an exacerbation of COPD. Further studies are necessary to determine the epidemiology and the impact of hMPV in COPD patients.
- Published
- 2005