1. Dynamics and phylogenetic relationships of HIV-1 transmitted drug resistance according to subtype in Italy over the years 2000-14
- Author
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Fabeni, L., Alteri, C., Di Carlo, D., Orchi, N., Carioti, L., Bertoli, A., Gori, C., Forbici, F., Continenza, F., Maffongelli, G., Pinnetti, C., Vergori, A., Mondi, A., Ammassari, A., Borghi, V., Giuliani, M., De Carli, G., Pittalis, S., Grisetti, S., Pennica, Alfredo, Mastroianni, Claudio Maria, Montella, F., Cristaudo, A., Mussini, C., Girardi, E., Andreoni, M., Antinori, A., Ceccherini silberstein, F., Perno, C. F., Santoro, M. M., Capobianchi, M. R., Navarra, A., Palummieri, A., Abbate, I., D'Arrigo, R., Fusco, F. M., Mariano, A., Nicastri, E., Nurra, G., Puro, V., Sampaolesi, A., Sciarrone, M. R., Scognamiglio, P., Selleri, M., Sias, C., Zaccarelli, M., Di Carlo, A., Vullo, Vincenzo, Falciano, Mario, Pennica, A., Errigo, F., Gattari, P., Spizzichino, L., Schito, S., Sarmati, L., Buonomini, A. R., Cerva, C., Mastroianni, C., Lichtner, Miriam, Mercurio, V. S., Anzalone, E., Pitorri, A., Caterini, A., and Aviani Barbacci, S.
- Subjects
0301 basic medicine ,Microbiology (medical) ,Adult ,Male ,medicine.medical_specialty ,Genotype ,Anti-HIV Agents ,Population ,Human immunodeficiency virus (HIV) ,HIV Infections ,Drug resistance ,Biology ,Molecular Dynamics Simulation ,medicine.disease_cause ,law.invention ,Men who have sex with men ,03 medical and health sciences ,pharmacology ,pharmacology (medical) ,infectious diseases ,HIV Protease ,law ,Internal medicine ,Epidemiology ,Drug Resistance, Viral ,medicine ,Prevalence ,Humans ,Pharmacology (medical) ,education ,Phylogeny ,Pharmacology ,education.field_of_study ,Phylogenetic tree ,Bayes Theorem ,Middle Aged ,Settore MED/07 - Microbiologia e Microbiologia Clinica ,Virology ,HIV Reverse Transcriptase ,030104 developmental biology ,Transmission (mechanics) ,Infectious Diseases ,Italy ,HIV-1 ,Female - Abstract
Background Transmitted drug-resistance (TDR) remains a critical aspect for the management of HIV-1-infected individuals. Thus, studying the dynamics of TDR is crucial to optimize HIV care. Methods In total, 4323 HIV-1 protease/reverse-transcriptase sequences from drug-naive individuals diagnosed in north and central Italy between 2000 and 2014 were analysed. TDR was evaluated over time. Maximum-likelihood and Bayesian phylogenetic trees with bootstrap and Bayesian-probability supports defined transmission clusters. Results Most individuals were males (80.2%) and Italian (72.1%), with a median (IQR) age of 37 (30-45) years. MSM accounted for 42.2% of cases, followed by heterosexuals (36.4%). Non-B subtype infections accounted for 30.8% of the overall population and increased over time (
- Published
- 2017