1. Use of linezolid in infants and children: a retrospective multicentre study of the Italian Society for Paediatric Infectious Diseases
- Author
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Monica Cellini, Ilaria Mariotti, Chiara Bertaina, Samantha Bosis, Anna Quondamcarlo, Pier-Angelo Tovo, Carlo Scolfaro, Laura Lancella, Elena Bozzola, Clara Gabiano, Marina De Gaudio, Annarosa Soresina, Giuseppe Losurdo, Silvia Garazzino, Lorenza Pugni, Alessandro Plebani, Luca Mancini, Carmelina Calitri, Susanna Esposito, Andrzej Krzysztofiak, Elio Castagnola, R. Lipreri, and Luisa Galli
- Subjects
Microbiology (medical) ,Male ,Pediatrics ,medicine.medical_specialty ,oxazolidinones ,paediatrics ,anaemia ,Adolescent ,Anemia ,INFANTS ,CHILDREN ,Neutropenia ,Gram-Positive Bacteria ,Mycobacterium ,chemistry.chemical_compound ,Acetamides ,Drug Resistance, Bacterial ,medicine ,LINEZOLID, INFANTS, CHILDREN ,Humans ,Pharmacology (medical) ,Adverse effect ,Child ,Gram-Positive Bacterial Infections ,Oxazolidinones ,Retrospective Studies ,Pharmacology ,Mycobacterium Infections ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,Linezolid ,Infant ,Retrospective cohort study ,medicine.disease ,Clinical trial ,Infectious Diseases ,Treatment Outcome ,chemistry ,Italy ,Child, Preschool ,Vomiting ,Female ,medicine.symptom ,Liver function tests ,business - Abstract
OBJECTIVES: Because of the spread of drug-resistant Gram-positive bacteria, the use of linezolid for treating severe infections is increasing. However, clinical experience in the paediatric population is still limited. We undertook a multicentre study to analyse the use of linezolid in children. METHODS: Hospitalized children treated with linezolid for a suspected or proven Gram-positive or mycobacterial infection were analysed retrospectively. Side effects were investigated, focusing on younger children and long-term treatments. RESULTS: Seventy-five patients (mean age 6.8 years, range 7 days to 17 years) were studied. Mean ± SD linezolid treatment duration was 26.13 ± 17 days. Clinical cure was achieved in 74.7% of patients. The most frequent adverse events were diarrhoea and vomiting. Two patients had severe anaemia, two neutropenia and one thrombocytopenia. Two cases of grade 3 liver function test elevation and one case of pancreatitis were reported. The overall frequency of adverse events was similar between patients treated for >28 days and those receiving shorter treatments (30.8% versus 28.6%, P = 0.84). Children aged
- Published
- 2011