1. Hypothalamic Region Facilitating Shivering in Rats
- Author
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Kei Nagashima, Mutsumi Tanaka, Kazuyuki Kanosue, Takayoshi Hosono, Motoko Yanase-Fujiwara, and Mio Tonouchi
- Subjects
Male ,Agonist ,Medial part ,medicine.medical_specialty ,animal structures ,Physiology ,medicine.drug_class ,Hypothalamus ,chemistry.chemical_compound ,Internal medicine ,medicine ,Animals ,Rats, Wistar ,Receptor ,GABA Agonists ,Neurons ,Muscimol ,business.industry ,Shivering ,Gaba agonists ,General Medicine ,Receptors, GABA-A ,Rats ,Endocrinology ,nervous system ,chemistry ,Excitatory postsynaptic potential ,medicine.symptom ,business - Abstract
Although the posterior part of the hypothalamus has long been considered important for thermoregulatory shivering, it is unknown whether the neurons there or the passing fibers are implicated in the response. Exposure of urethane-anesthetized rats to cold (15-21 degrees C) elicits shivering. An injection of muscimol (0.5 mM), a GABA(A) receptor agonist, into the medial part of the hypothalamus, including the dorsomedial and posterior nuclei, suppressed the cold-induced shivering. This result suggests that neurons having an excitatory effect on shivering are in this region of the hypothalamus.
- Published
- 2001
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