1. 3.0 T magnetic resonance myocardial perfusion imaging for semi-quantitative evaluation of coronary microvascular dysfunction in hypertrophic cardiomyopathy
- Author
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Ying Zhu, Hai-yan Xu, Lianggeng Gong, Wei Zhou, Liang Yin, Sisi Yu, Sui-sheng Zheng, and Jiang-Xi Xiao
- Subjects
Gadolinium DTPA ,Male ,Contrast Media ,030204 cardiovascular system & hematology ,Severity of Illness Index ,Ventricular Function, Left ,030218 nuclear medicine & medical imaging ,Muscle hypertrophy ,0302 clinical medicine ,Medicine ,Cardiac imaging ,medicine.diagnostic_test ,Ventricular Remodeling ,Hypertrophic cardiomyopathy ,Myocardial Perfusion Imaging ,Middle Aged ,Prognosis ,Coronary Vessels ,embryonic structures ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Perfusion ,Adult ,medicine.medical_specialty ,Magnetic Resonance Imaging, Cine ,03 medical and health sciences ,Myocardial perfusion imaging ,Predictive Value of Tests ,Internal medicine ,Coronary Circulation ,Image Interpretation, Computer-Assisted ,Late gadolinium enhancement ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Aged ,business.industry ,Microcirculation ,Myocardium ,Reproducibility of Results ,Magnetic resonance imaging ,Cardiomyopathy, Hypertrophic ,medicine.disease ,Fibrosis ,Case-Control Studies ,Microvessels ,Myocardial fibrosis ,business - Abstract
This study aimed to assess coronary microvascular dysfunction (CMD) differences in hypertrophic cardiomyopathy (HCM) patients using cardiac magnetic resonance (CMR) first-pass perfusion and late gadolinium enhancement imaging. Forty-seven patients with HCM and twenty-one healthy volunteers underwent CMR at rest. Imaging protocols included short axis cine, first-pass myocardial perfusion, and late gadolinium enhancement (LGE). Left ventricular end-diastolic wall thickness (EDTH), LGE, time to peak (Tpeak), maximal up-slope (Slopemax), and peak signal intensity (SIpeak) were assessed for each myocardial segment. The HCM myocardial segments were grouped by the degree of LGE and hypertrophy. Tpeak, SIpeak, Slopemax and EDTH in multiple groups were assessed and compared by ANOVA test/Kruskal–Wallis test. The Spearman correlation test was used to determine the relationships between EDTH, LGE and perfusion parameters (Tpeak, Slopemax and SIpeak). Compared to control group segments, Tpeak increased while Slopemax and SIpeak decreased in non-LGE/non-hypertrophic segments and LGE/hypertrophic segments in the HCM group, while Tpeak increased more significantly in LGE/hypertrophic segments (all p
- Published
- 2017