1. Cardiac magnetic resonance and galectin-3 level as predictors of prognostic outcomes for non-ischemic cardiomyopathy patients
- Author
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Ya-Nan Zhou, Min Zhong, Da-Jun Hu, Wei Du, Jing Xu, and Jian-Xin Zhang
- Subjects
Male ,Multivariate analysis ,Galectin 3 ,Cardiomyopathy ,Contrast Media ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,0302 clinical medicine ,Prospective Studies ,030212 general & internal medicine ,Ventricular Remodeling ,Hazard ratio ,Hypertrophic cardiomyopathy ,Dilated cardiomyopathy ,Blood Proteins ,Middle Aged ,Prognosis ,Magnetic Resonance Imaging ,Up-Regulation ,Galectin-3 ,Area Under Curve ,embryonic structures ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Adult ,Cardiomyopathy, Dilated ,medicine.medical_specialty ,Galectins ,03 medical and health sciences ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Survival analysis ,Aged ,Proportional Hazards Models ,Chi-Square Distribution ,Proportional hazards model ,business.industry ,Reproducibility of Results ,Stroke Volume ,Cardiomyopathy, Hypertrophic ,medicine.disease ,ROC Curve ,Multivariate Analysis ,business ,Biomarkers - Abstract
This study was aimed at determining whether late gadolinium enhancement (LGE) in conjunction with Galectin-3 (Gal-3) level offered more precise prognosis of non-ischemic cardiomyopathy (NICM) in comparison to LGE alone. Results of LGE and Gal-3 expression in 192 patients with NICM, including 85 subjects with dilated cardiomyopathy (DCM) and 107 with hypertrophic cardiomyopathy (HCM), were examined. As suggested by the characteristics of LGE and Gal-3 levels, patients were divided into four groups: LGE positive + low Gal-3 (n = 10 for DCM, n = 15 for HCM), LGE positive + high Gal-3 (n = 25 for DCM, n = 51 for HCM), LGE negative + low Gal-3 (n = 32 for DCM, n = 29 for HCM), LGE negative + high Gal-3 (n = 18 for DCM, n = 12 for HCM). Primary endpoints over the follow-up period included major adverse cardiac events (MACEs). Kaplan–Meier survival analysis and univariate Cox proportional hazard models were used to analyze the survival status of patients with NICM. The optimal cut-off value of Gal-3 level for two types of NICM was determined by receiver operating characteristic analysis (13.38 U/L for DCM and 14.40 U/L for HCM). The combination of LGE and Gal-3 levels offered a more significant prognostic value than using LGE alone for both DCM and HCM (DCM P = 0.001
- Published
- 2016
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