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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the worldwide, and occurs in patients who do not abuse alcohol. Metabolic syndrome is a major risk in the progression of NAFLD, steatosis and NASH (nonalcoholic steatohepatitis). In addition, obesity induced chronic low-grade inflammation also play a crucial role in NAFLD formation. P-selectin, an adhesion molecule, regulates leukocyte aggregation to vascular endothelium cell, induces the initial inflammatory response. In the study, we aimed to investigate the impact of P-selectin deficiency on high fat diet (45% caloric from fat, HFD) induced NAFLD. C57BL6 wild-type mice and P-selectin KO mice were randomly divided into four groups, and fed with normal chow diet or HFD : wild-type fed with chow diet (C) or high-fat diet (H), P-selectin KO mice fed with chow-diet (PC) or high fat diet (PH). After 8 weeks HFD feeding, significantly increase body weight in wild-type mice. The mice also exhibited higher liver weight...

Chronic inflammation is widely observed in obese individuals, and trigger insulin resistance and type 2 diabetes. P-selectin is a cell adhesion molecule which expressed on the surface of activated ...