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Vitamin K is an essential nutrient that has been implicated in cardiovascular disease and other chronic diseases. There are multiple forms of vitamin K. Phylloquinone (PK, vitamin K1) is plant-base...

Phylloquinone (PK) and menaquinone (MK) are naturally-occurring forms of vitamin K (VK).There is selective tissue distribution and conversion of dietary PK to MK4, providing indirect evidence of un...

The tissue-specific response to dietary vitamin K (VK) manipulation has not been well studied in mice. This limits the use of genetically modified mouse models in VK studies. The objective of this study was to determine the sex-specific effects of dietary VK manipulation on serum, liver and extra-hepatic tissue VK concentrations in C57BL/6 mice (n=64). Mice were weight-matched and pair-fed a control diet (1.4±0.08 mg phylloquinone (PK) /kg) or VK-deficient diet (31±0.45 µg PK/kg) for 28 days. Liver, kidney, brain, pancreas, adipose tissue, and serum PK and menaquinone-4 (MK-4) concentrations were measured by HPLC. Data were log transformed and analyzed by a general linear model, stratified by diet. Male and female mice responded differently to dietary manipulation of VK in a tissue-dependent manner (for all sex by diet interactions p 0.95); no serum MK-4 was detected. Females on the control diet had significantly ...