Search

Your search keyword '"T Gewirtz A"' showing total 24 results
Start Over Author "T Gewirtz A" Journal the faseb journal
24 results on '"T Gewirtz A"'

1. Early Breastfeeding Initiation, Prelacteal Feeding, and Infant Feeding Are Associated with Biomarkers of Environmental Enteric Dysfunction

Author

Karim Manji, Rodrick Kisenge, Andrew T. Gewirtz, Christopher Duggan, Kerri Gosselin, Christine McDonald, Wafaie W. Fawzi, and Emily R. Smith

Subjects
0301 basic medicine, 03 medical and health sciences, 030109 nutrition & dietetics, business.industry, Genetics, Breastfeeding, Physiology, Medicine, business, Molecular Biology, Biochemistry, Infant feeding, Biotechnology
Published
2017

3. Infant nutritional status and markers of environmental enteric dysfunction are associated with mid‐childhood anthropometry and blood pressure in Tanzania

Author

Karim Manji, Expeditho Mtisi, Rodrick Kisenge, Andrew T. Gewirtz, Lindsey M. Locks, M.W. Gillman, Kerri Gosselin, Ramadhani S. Mwiru, Christine McDonald, Said Aboud, Roland Kupka, Enju Liu, Wafaie W. Fawzi, and Christopher Duggan

Subjects
biology, business.industry, Nutritional status, Anthropometry, biology.organism_classification, Biochemistry, Tanzania, Blood pressure, Environmental health, Genetics, Medicine, business, Molecular Biology, Biotechnology
Published
2017

4. Gut Microbiota, Low‐Grade Inflammation, and Metabolic Syndrome

Author

Andrew T. Gewirtz

Subjects
Low grade inflammation, biology, Immunology, Gut–brain axis, Genetics, medicine, Metabolic syndrome, Gut flora, medicine.disease, biology.organism_classification, Molecular Biology, Biochemistry, Biotechnology
Published
2015

5. Effects of Calcium and Vitamin D Supplementation on Markers of Colonic Permeability

Author

Andrew T. Gewirtz, Hao Quang Tran, Elizabeth L. Barry, Veronika Fedirko, Roberd M. Bostick, and John A. Baron

Subjects
medicine.medical_specialty, Vitamin d supplementation, Gut barrier, business.industry, digestive, oral, and skin physiology, Inflammatory Bowel Diseases, chemistry.chemical_element, Colorectal carcinogenesis, Calcium, Biochemistry, Endocrinology, chemistry, Permeability (electromagnetism), Internal medicine, Genetics, medicine, Vitamin D and neurology, business, Molecular Biology, Biotechnology
Abstract

Impaired gut barrier function contributes to inflammatory bowel diseases and colorectal carcinogenesis. Recent evidence from experimental models indicates that calcium and vitamin D may beneficiall...

Published
2015

6. Markers of Environmental Enteric Dysfunction (EED) are Associated with Neurodevelopment in Tanzanian Children

Author

Andrew T. Gewirtz, Karim Manji, Christine McDonald, Christopher Duggan, Rodrick Kisenge, David C. Bellinger, Kerri Gosselin, Hao Tran, Analee J. Etheredge, Mark D. Kellogg, Said Aboud, and Wafaie W. Fawzi

Subjects
Oncology, medicine.medical_specialty, Increased risk, business.industry, Internal medicine, Genetics, Medicine, business, Molecular Biology, Biochemistry, Biotechnology
Abstract

Background: Children with environmental enteric dysfunction (EED) are at increased risk for impaired growth and neurodevelopment. We conducted a study to evaluate novel biomarkers of gastrointestin...

Published
2015

7. Metabolic syndrome in TLR5 deficient mice is associated with microbiota dependent MUFA enriched hepatic lipids (133.6)

Author

Matam Vijay-Kumar, Manish Kumar, Benoit Chassaing, and Andrew T. Gewirtz

Subjects
medicine.medical_specialty, Leptin Deficiency, biology, Cholesterol, Phospholipid, Gut flora, biology.organism_classification, medicine.disease, Biochemistry, TLR2, chemistry.chemical_compound, Endocrinology, chemistry, TLR5, Internal medicine, Genetics, medicine, lipids (amino acids, peptides, and proteins), Metabolic syndrome, Receptor, Molecular Biology, Biotechnology
Abstract

Obesity (leptin deficiency) is associated with elevated monounsaturated fatty acids (MUFA) specifically palmitoleate (C16:1) and oleate (C18:1) in tissue neutral lipids. Toll Like Receptor 5 (TLR5), an innate immune receptor for bacterial flagellin is required for gut microbiota homeostasis. Accordingly, mice lacking TLR5 (TLR5KO) develop spontaneous low-grade gut inflammation and metabolic syndrome, which are microbiota dependent. Here, we examined whether metabolic syndrome in TLR5KO mice is associated with elevated MUFA levels. We analyzed fatty acid composition of total lipid (TL), triglycerides (TG), cholesterol esters (CE) and phospholipid (PL) fractions of the tissue lipids in age and gender matched TLR5KO and their WT littermates. We also analyzed MUFA levels in high-fat fed, TLR2 or 4 deficient TLR5KO, calorie restricted, microbiota ablated, germ-free (GF) and conventionalized GF-WT mice transplanted with either WT or TLR5KO microbiota. TLR5KO mice displayed elevated hepatic TG and CE and substan...

Published
2014

8. Colonic leptin: source of a novel pro‐inflammatory cytokine involved in inflammatory bowel disease

Author

Shanthi V. Sitaraman, Didier Merlin, Xia Liu, Thomas R. Ziegler, Li Hao Gu, Laetitia Charrier, and Andrew T. Gewirtz

Subjects
medicine.medical_specialty, Leptin, digestive, oral, and skin physiology, Adipokine, Biology, medicine.disease, Biochemistry, Inflammatory bowel disease, Intestinal absorption, Small intestine, Proinflammatory cytokine, Endocrinology, medicine.anatomical_structure, Internal medicine, Genetics, medicine, Receptor, Molecular Biology, Biotechnology, Hormone
Abstract

SPECIFIC AIMSLeptin, the obesity gene cloned in 1994, is produced mainly by adipocytes and is the key hormone involved in central regulation of body weight. Leptin acts through specific receptors in the brain to control food intake. Studies have shown that nonadipose tissues such as skeletal muscle, pituitary gland, and stomach can also produce leptin; it therefore it reaches the small intestine in an active form and can locally initiate biological processes involved in regulating functions, such as intestinal absorption. The aim of the present study is to determine whether colonic epithelial cells produce leptin and might contribute to pathological states such as inflammatory bowel disease (IBD).PRINCIPAL FINDINGS1. Inflamed colonic epithelial cells express leptinIn the present report we show for the first time that inflamed colonic epithelial cells express leptin concentrated at a subapical part of colonic cells (Fig. 1⤻ B1–B3); leptin was not detected in normal colonic epithelial cells (Fig. 1A1-A3⤻ )....

Published
2004

15. Toll‐like receptor‐4 (TLR‐4) deficiency did not offer protection against trans fat or high fat diet‐induced hyperinsulinemia and hyperglycemia in mice

Author

Matam Vijay-Kumar, Vijay Ganji, Jesse D. Aitken, and Andrew T. Gewirtz

Subjects
medicine.medical_specialty, Trans fat, Toll-like receptor, business.industry, High fat diet, medicine.disease, Biochemistry, Endocrinology, Internal medicine, Genetics, Hyperinsulinemia, Medicine, business, Molecular Biology, Biotechnology
Published
2009

19. Adenosine 2b receptor blockade inhibits pro‐inflammatory events in the intestine

Author

Andrew T. Gewirtz, Joel Linden, Shanthi V. Sitaraman, Lixin Wang, Vasantha L. Kolachala, Vijay Kumar Matham, Didier Merlin, and Shanthi Srinivasan

Subjects
Adenosine A1 receptor, Receptor blockade, Chemistry, Genetics, medicine, Purinergic signalling, Pharmacology, Adenosine A3 receptor, Molecular Biology, Biochemistry, Adenosine, Biotechnology, medicine.drug
Published
2008

24. Dietary glutamine increases secretory IgA and may suppress gram‐negative bacterial translocation in a rat model of short bowel syndrome (SBS)

Author

Andrew T. Gewirtz, Dean P. Jones, Ifor R. Williams, Thomas R. Ziegler, Junqiang Tian, Li H. Gu, and Prakash Chandra

Subjects
Rat model, Bacterial translocation, Biology, Short bowel syndrome, medicine.disease, Biochemistry, Microbiology, Glutamine, Immunology, Genetics, medicine, Secretory IgA, Molecular Biology, Biotechnology, Gram
Published
2006

Catalog

Books, media, physical & digital resources
See catalog results